Novel dihydropyridine thioglycosides and their corresponding dehydrogenated forms as potent anti-hepatocellular carcinoma agents
Autor: | Galal H. Elgemeie, Dina H. El-Naggar |
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Rok vydání: | 2018 |
Předmět: |
Dihydropyridines
Carcinoma Hepatocellular Cell Survival Antineoplastic Agents 01 natural sciences Biochemistry Liver carcinoma chemistry.chemical_compound Structure-Activity Relationship Pyridine Genetics medicine Humans Dehydrogenation Cell Proliferation Molecular Structure 010405 organic chemistry Liver Neoplasms Dihydropyridine General Medicine Hep G2 Cells medicine.disease Combinatorial chemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Cell culture Thioglycosides Hepatocellular carcinoma Drug Design Molecular Medicine Oxidation-Reduction medicine.drug |
Zdroj: | Nucleosides, nucleotidesnucleic acids. 37(4) |
ISSN: | 1532-2335 |
Popis: | A novel method for preparation of a new class of dihydropyridine thioglycosides and their corresponding dehydrogenated forms, via reaction of piperidinium salts of dihydropyridinethiones with 2,3,4,6-tetra-O-acetyl-α-D-gluco- and galactopyranosyl bromides has been studied. The evaluation of antiproliferative activity against HepG-2 cell lines (liver carcinoma cell lines) of the dihydropyridine thioglycosides and pyridine thioglycosides revealed that many of the thioglycosides have interesting antitumor activities specifically 5c, 5g, 5l, 5o, 5p, 7a, 7i, 7p, 8b, 8f, 8s, and 8v. |
Databáze: | OpenAIRE |
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