The diagnostic value of water immersion skin wrinkling and Neuropads in small fiber neuropathy
| Autor: | Elske Hoitsma, J. Gert van Dijk, Mirjam Datema |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Peripheral neuropathy Gastroenterology Sensitivity and Specificity Polyneuropathies Physiology (medical) Daily practice Internal medicine Immersion medicine Humans Small Fiber Neuropathy Aged Aged 80 and over Neurologic Examination Sudomotor testing business.industry Diagnostic test Water Middle Aged medicine.disease Sensory Systems Neurology Water immersion Diagnostic tests Female Neurology (clinical) Abnormality Small fiber neuropathy business |
| Zdroj: | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 123(10) |
| ISSN: | 1872-8952 |
| Popis: | Objective To investigate the diagnostic yield of two simple tests for small fiber neuropathy (SFN): Neuropads® and water immersion skin wrinkling (WISW). Methods We studied 35 patients clinically diagnosed with SFN and 61 age- and sex-matched healthy controls. Wrinkling was judged as absent (abnormal), or present (normal) after immersion of the hands for 30 min. Neuropads® are plasters impregnated with cobalt blue that are applied with to the soles of the feet. These remain blue when feet are dry (abnormal) or turn pink when there is some moisture (normal). Results The sensitivity of the Neuropad® was 29% and its specificity 93%. The sensitivity of WISW was 66% and its specificity 70%. Regarding abnormality of at least one test to define the combination as abnormal yielded a sensitivity of 71% and specificity 67%. When both tests had to be abnormal to judge the combination abnormal, sensitivity was 23% and specificity 97%. Conclusions The Neuropad® has a high specificity, so an abnormal result can be used to confirm SFN. WISW has a moderate sensitivity and specificity. Combining these two tests can be helpful: when both tests are abnormal the diagnosis SFN is highly likely. Significance The Neuropad® and WISW can be helpful in daily practice by supporting the diagnosis SFN. |
| Databáze: | OpenAIRE |
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