MR-spectroscopy of hepatic-fat and adiponectin and leptin levels during testosterone therapy in type 2 diabetes:A randomized, double-blinded, placebo-controlled trial
| Autor: | Jelena Ostojic, Marianne Andersen, Kurt Højlund, Anabel Diaz, Torben Leo Nielsen, Line Velling Magnussen, Poul Erik Andersen, Anders Christensen, David M. Hougaard |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Leptin
Male medicine.medical_specialty Magnetic Resonance Spectroscopy Hormone Replacement Therapy Endocrinology Diabetes and Metabolism Testosterone/administration & dosage Adipokine Adipose tissue 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Placebo 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology High-density lipoprotein Double-Blind Method Liver/drug effects Internal medicine medicine Humans Testosterone Aged Magnetic Resonance Spectroscopy/methods Adiponectin business.industry Cholesterol General Medicine Middle Aged medicine.disease Hormone Replacement Therapy/methods chemistry Diabetes Mellitus Type 2 Liver Leptin/blood Adiponectin/blood business Diabetes Mellitus Type 2/blood |
| Zdroj: | Magnussen, L V, Andersen, P E, Diaz, A, Ostojic, J M, Højlund, K, Hougaard, D M, Christensen, A N, Nielsen, T L & Andersen, M S 2017, ' MR-spectroscopy of hepatic-fat and adiponectin and leptin levels during testosterone therapy in type 2 diabetes : A randomized, double-blinded, placebo-controlled trial ', European Journal of Endocrinology. Supplement, vol. 177, no. 2, pp. 157-168 . https://doi.org/10.1530/EJE-17-0071 |
| Popis: | Background Men with type 2 diabetes mellitus (T2D) often have lowered testosterone levels and an increased risk of cardiovascular disease (CVD). Ectopic fat increases the risk of CVD, whereas subcutaneous gluteofemoral fat protects against CVD and has a beneficial adipokine-secreting profile. Hypothesis Testosterone replacement therapy (TRT) may reduce the content of ectopic fat and improve the adipokine profile in men with T2D. Design and methods A randomized, double-blinded, placebo-controlled study in 39 men aged 50–70 years with T2D and bioavailable testosterone levels n = 20) or placebo gel (n = 19) for 24 weeks. Thigh subcutaneous fat area (TFA, %fat of total thigh volume), subcutaneous abdominal adipose tissue (SAT, % fat of total abdominal volume) and visceral adipose tissue (VAT, % fat of total abdominal volume) were measured by magnetic resonance (MR) imaging. Hepatic fat content was estimated by single-voxel MR spectroscopy. Adiponectin and leptin levels were measured by in-house immunofluorometric assay. Coefficients (b) represent the placebo-controlled mean effect of intervention. Results TFA (b = −3.3 percentage points (pp), P = 0.009), SAT (b = −3.0 pp, P = 0.006), levels of adiponectin (b = −0.4 mg/L, P = 0.045), leptin (b = −4.3 µg/mL, P b = −0.53, P = 0.001) and HDL cholesterol (b = −0.11 mmol/L, P = 0.009) decreased during TRT compared with placebo. Hepatic fat content and VAT were unchanged. Conclusions The effects of TRT on cardiovascular risk markers were ambiguous. We observed potentially harmful changes in cardiovascular risk parameters, markedly reduced subcutaneous fat and unchanged ectopic fat during TRT and a reduction in adiponectin levels. On the other hand, the decrease in leptin and leptin:adiponectin ratio assessments could reflect an amelioration of the cardiovascular risk profile linked to hyperleptinaemia in ageing men with T2D. |
| Databáze: | OpenAIRE |
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