Preconditioning with cobalt chloride modifies pain perception in mice
| Autor: | CR Bohotin, Andrei Luca, A. Dondas, Teodora Alexa |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Cancer Research
medicine.medical_specialty hypoxia business.industry Ischemia analgesia Articles General Medicine Cobalt chloride Pharmacology Hypoxia (medical) medicine.disease Inflammatory pain Locomotor activity Surgery cobalt chloride Immunology and Microbiology (miscellaneous) Apoptosis Hyperalgesia medicine Pain perception medicine.symptom locomotor activity business hyperalgesia |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| DOI: | 10.3892/etm.2015.2235 |
| Popis: | Cobalt chloride (CoCl2) modifies mitochondrial permeability and has a hypoxic-mimetic effect; thus, the compound induces tolerance to ischemia and increases resistance to a number of injury types. The aim of the present study was to investigate the effects of CoCl2 hypoxic preconditioning for three weeks on thermonociception, somatic and visceral inflammatory pain, locomotor activity and coordination in mice. A significant pronociceptive effect was observed in the hot plate and tail flick tests after one and two weeks of CoCl2 administration, respectively (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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