Optimization and Application of an Efficient and Stable Inhalation Exposure System for Rodents

Autor:	Zi Fan, Bo Zhou, Yujia Liu, Wu Sun, Yuntao Fang, Hongguo Lu, Dongya Chen, Kuikui Lu, Xinyue Wu, Tian Xiao, Wenjing Xie, Qian Bian
Rok vydání:	2021
Předmět:	Aerosols Inhalation Exposure Ecology Pharmaceutical Science Rodentia General Medicine Aquatic Science Glycopyrrolate Rats Rats Sprague-Dawley Drug Discovery Administration Inhalation Animals Agronomy and Crop Science Lung Ecology Evolution Behavior and Systematics
Zdroj:	AAPS PharmSciTechREFERENCES. 23(1)
ISSN:	1530-9932
Popis:	Inhalation is a promising and challenging method in pharmaceutical and biological science research. A stable environment is critical in dynamic inhalation administration. However, the establishment of a stable inhalation system is very challenging. Indacaterol glycopyrronium bromide inhalation powder (IM/GP mixed powder) is composed of indacaterol maleate and glycopyrronium bromide powder to treat chronic obstructive pulmonary disease (COPD). The aim of this study is to build suitable inhalation conditions and then to evaluate the pulmonary safety of this drug in Sprague-Dawley(SD) rats. In the research, through the coordination of the atomization flow, air pump flow, and scraper speed, aerosols were stabilized at 200 ± 20% mg/m
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf088d0aa787f4ab7afec978ec10839 https://pubmed.ncbi.nlm.nih.gov/34993683 Zobrazit plný text záznamu Full text from SpringerLink