Coupled oxygen transport analysis in the avascular wall of a coronary artery stenosis during angioplasty
| Autor: | Lloyd H. Back, Vinayak S. Vaidya, Ohwon Kwon, Rupak K. Banerjee |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Percutaneous transluminal coronary angioplasty medicine.medical_treatment Biomedical Engineering Biophysics Biological Transport Active chemistry.chemical_element Coronary stenosis Oxygen Internal medicine Angioplasty medicine Humans Computer Simulation Orthopedics and Sports Medicine Arterial wall Angioplasty Balloon Coronary business.industry Rehabilitation Coronary Stenosis Models Cardiovascular Oxygen transport medicine.disease Coronary Vessels Stenosis medicine.anatomical_structure chemistry Vasa vasorum Cardiology business |
| Zdroj: | Journal of Biomechanics. 41:475-479 |
| ISSN: | 0021-9290 |
| DOI: | 10.1016/j.jbiomech.2007.09.011 |
| Popis: | The coupled oxygen transport in the avascular wall of a coronary artery stenosis is studied numerically by solving the convection–diffusion equations. Two geometries replicating stenosis before and after percutaneous transluminal coronary angioplasty (PTCA) are used for the analysis. The results are compared to evaluate the effect of the degree of stenosis on oxygen transport. Important physiological aspects, such as oxygen consumption in the wall, oxygen carried by the hemoglobin, non-Newtonian viscosity of the blood, and supply of oxygen from the vasa vasorum are included. The results show that the P O 2 in the medial region of the arterial wall is ∼10 mmHg. The oxygen flux to the wall increases in the flow acceleration region, whereas it decreases at the flow reattachment zone. Near the location of flow separation, there is a small rise followed by a sharp fall in the oxygen flux. The drop in the oxygen flux to the wall at the point of flow reattachment for pre-PTCA stenosis is four times that for post-PTCA stenosis. The minimum P O 2 in the avascular wall, P O 2 , min , at this location decreases to ∼6.0 and 4.2 mmHg for post- and pre-PTCA stenosis, respectively. The drop in P O 2 , w and P O 2 , min at the point of flow reattachment for pre-PTCA is ∼2 times that for post-PTCA stenosis. Thus, the present study quantifies the oxygen transport to the arterial wall before and after cardiovascular intervention. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect