Canine thyroid carcinoma prognosis following the utilisation of computed tomography assisted staging

Autor: Nele Van Den Steen, Patricia Trish Ward, Tim Trevail, Jenny Ellis, Emma Roberts, Steven P. Rushton, Rory Bell, Aldara Eiras, Chiara Giannasi, Valerie Lamb, Francesca Venier, Alice Rook
Rok vydání: 2021
Předmět:
Zdroj: Veterinary Record. 189
ISSN: 2042-7670
0042-4900
DOI: 10.1002/vetr.55
Popis: BACKGROUND Metastatic disease is frequently present at the time of diagnosis of canine thyroid carcinoma; however, utilisation of computed tomography (CT) alone for staging pre-treatment has been rarely reported in the veterinary literature. METHODS The aims of this retrospective study were to stage affected dogs using CT findings of the cervical and thoracic regions, combined with histopathology/cytology results, in order to assess whether metastatic disease/WHO staging was of prognostic significance. RESULTS Fifty-eight dogs were included in the study. Classification of cases into WHO stages I, II, III and IV were 10%, 50%, 9% and 31%, respectively. No statistically significant effect of WHO stage classification on overall survival/follow-up time was found (P = .576). Surgery resulted in a statistically significant increase in overall survival/follow-up time (P < .01). There was no statistically significant effect on overall survival/follow-up time in dogs that received medical therapy, either as sole therapy or as an adjunctive post-surgery (P = .198). CONCLUSION In summary, this study documents the metastatic rate of canine thyroid carcinoma using CT for staging pre-treatment. Staging utilising CT revealed a higher distant metastatic rate in dogs with thyroid carcinoma when compared to historical studies using different imaging techniques. As long-term outcomes are possible for cases with advanced disease, surgical intervention could still be considered.
Databáze: OpenAIRE
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