Paraquat-Induced Movement Disorder in Relation to Oxidative Stress-Mediated Neurodegeneration in the Brain of Drosophila melanogaster
Autor: | S. Niveditha, Thimmappa Shivanandappa, Saraf R. Ramesh |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Male Paraquat Movement disorders ved/biology.organism_classification_rank.species Pharmacology Mitochondrion medicine.disease_cause Biochemistry Neuroprotection 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine medicine Animals Model organism Movement Disorders biology Dose-Response Relationship Drug ved/biology Herbicides Neurodegeneration Brain Neurodegenerative Diseases General Medicine biology.organism_classification medicine.disease Oxidative Stress 030104 developmental biology Drosophila melanogaster chemistry Female Lipid Peroxidation medicine.symptom Neuroscience 030217 neurology & neurosurgery Oxidative stress |
Zdroj: | Neurochemical research. 42(11) |
ISSN: | 1573-6903 |
Popis: | Exposure to pesticides like paraquat (PQ) is considered as a risk factor for Parkinson's disease (PD). PQ has been shown to induce PD-like phenotype in experimental animals. Drosophila, a valuable laboratory model organism, is widely used to study neurodegenerative disorders including PD. The acute (single dose) PQ model of PD in Drosophila is associated with high mortality as well as reversibility of locomotor deficits and, therefore, does not replicate the disease phenotype. We have investigated the relevance of the acute and multiple (sublethal) dose of PQ to induce PD-like symptoms in Drosophila and shown that multiple-dose of PQ induces irreversible locomotor impairment without significant mortality. Our study has provided ultrastructural evidence for neurodegeneration involving mitochondrial damage in the brain caused by free radical-induced oxidative stress, which leads to locomotor impairment in Drosophila. The multiple (sublethal) dose of PQ could be an appropriate Drosophila model to induce PD-like symptoms of movement disorder associated with neurodegeneration, which could be useful to evaluate neuroprotective compounds. |
Databáze: | OpenAIRE |
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