Lack of Association Between Essential Hypertension and GSTO1 Uncommon Genetic Variants in Italian Patients
| Autor: | Maria Antonietta Re, Sara Piacentini, Renato Polimanti, Natalia Lazzarin, Maria Fuciarelli, Dario Manfellotto |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Genotype European Continental Ancestry Group Biology Settore BIO/08 Essential hypertension White People Sex Factors Genetic Gene Frequency Statistical significance medicine Humans Polymorphism Genetic Glutathione Transferase Italy Haplotypes Middle Aged Female Hypertension Genetic variability Polymorphism Association (psychology) Genetics (clinical) Genetics Haplotype Genetic variants General Medicine medicine.disease Phenotype |
| Zdroj: | Genetic Testing and Molecular Biomarkers. 16:615-620 |
| ISSN: | 1945-0257 1945-0265 |
| DOI: | 10.1089/gtmb.2011.0310 |
| Popis: | Essential hypertension (EH) is a complex phenotype that is affected by multiple genetic and environmental factors. Some authors have explored the role of genetic variability of the glutathione S-transferase (GST) enzymes in EH risk with contrasting results. In particular, our previous study investigated two GSTO common polymorphisms, but we did not find a significant outcome. The aim of this research was to analyze two GSTO1 uncommon variants (E155del and E208K) in 193 EH patients and 210 healthy controls.The genetic association analysis did not find significant outcome between GSTO1 uncommon variants and EH: both single-locus and haplotype investigations did not reach the statistical significance levels. Nevertheless, the correspondence analysis seems to highlight a difference between sexes: female EH patients seem to be more related to E155/del155 and E208/K208 genotypes than male patients.Our studies confirm the lack of association between GSTO1 variants and EH risk, also for two uncommon genetic variants with large functional effects. However, our study highlighted some hypotheses (sex-specific marker, antioxidant function, arsenic metabolism, and modulation of inflammation processes) that might help to clarify the potential role of GSTO1 in EH pathophysiology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|