Lung Perfusion MRI After Congenital Diaphragmatic Hernia Repair in 2-Year-Old Children With and Without Extracorporeal Membrane Oxygenation Therapy
| Autor: | Katrin Zahn, K. Wolfgang Neff, Frank G. Zoellner, Stefan O. Schoenberg, Meike Weis, C Hagelstein, Thomas Schaible |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Pulmonary Circulation medicine.medical_treatment Blood volume 030218 nuclear medicine & medical imaging 03 medical and health sciences Extracorporeal Membrane Oxygenation 0302 clinical medicine 030225 pediatrics medicine Extracorporeal membrane oxygenation Humans Radiology Nuclear Medicine and imaging Lung hypoplasia Herniorrhaphy Lung medicine.diagnostic_test business.industry Age Factors Infant Newborn Infant Congenital diaphragmatic hernia Lung perfusion General Medicine medicine.disease Magnetic Resonance Imaging Treatment Outcome surgical procedures operative medicine.anatomical_structure Child Preschool Anesthesia Angiography Female Hernias Diaphragmatic Congenital business Perfusion Follow-Up Studies |
| Zdroj: | American Journal of Roentgenology. 206:1315-1320 |
| ISSN: | 1546-3141 0361-803X |
| DOI: | 10.2214/ajr.15.14860 |
| Popis: | In severe cases of congenital diaphragmatic hernia (CDH), extracorporeal membrane oxygenation (ECMO) therapy improves survival. Later on, lung morbidity mainly defines development. The purpose of this study was to investigate whether 2-year-old children who need ECMO therapy after delivery have reduced perfusion MRI values as a sign of more severe lung hypoplasia than do children who do not need ECMO.After CDH repair, 38 children underwent dynamic contrast-enhanced MRI with a 3D time-resolved angiography with stochastic trajectories sequence. Fifteen (39%) of the children had received ECMO therapy in the neonatal period. Pulmonary blood flow (PBF), pulmonary blood volume (PBV), and mean transit time were calculated for both lungs. In addition, the ratio of ipsilateral to contralateral lung was calculated for all parameters.In all children, those with and those without ECMO requirement, PBF and PBV were significantly reduced on the ipsilateral side (p0.05). Children who had received ECMO therapy had significantly reduced PBF and PBV values on the ipsilateral side (p0.05) compared with children who had not needed ECMO therapy. The ratios of ipsilateral to contralateral lung for PBF and PBV were also significantly reduced after ECMO.Two-year-old children undergoing CDH repair who had needed neonatal ECMO had significantly reduced perfusion MRI values in the ipsilateral lung in comparison with children who had not needed ECMO. Perfusion MRI measurements are associated with the severity of lung hypoplasia and may therefore be helpful in follow-up investigations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|