Effect of Parathyroid Extract on Renal Cyclic AMP Excretion in Patients with Normocalciuric Nephrolithiasis
| Autor: | K G Mackes, H v Lilienfeld-Toal, U. Klehr, H J Dengler |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Urinary system Clinical Biochemistry Stimulation Biochemistry Excretion Kidney Calculi Basal (phylogenetics) Endocrinology Calcium Metabolism Disorders Internal medicine Cyclic AMP medicine Humans In patient Aged Calcium metabolism business.industry Hyperparathyroidism Liver Diseases Biochemistry (medical) General Medicine Middle Aged medicine.disease Urinary calcium Parathyroid Hormone Calcium Female business Primary hyperparathyroidism |
| Zdroj: | Hormone and Metabolic Research. 10:158-161 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-0028-1093466 |
| Popis: | It is uncertain whether normocalcemic, normocalciuric patients with calcium nephrolithiasis have a disorder of calcium metabolism. We studied the effect of a parathyroid extract (PTE) INFUSION (1.4 U/kg body weight) on the urinary cyclic AMP excretion in 16 such patients. For comparison, we investigated groups of normal individuals and patients with primary hyperparathyroidism, renal insufficiency and different gastrointestinal diseases. The increase of cyclic AMP above basal excretion in patients with nephrolithiasis was only 1.2 +/- 0.3 mumol/h (mean +/- SEM), versus 2.5 +/- 0.5 mumol/h in normal subjects (p less than 0.05) although the basal excretion was similar. Patients with renal insufficiency had low basal excretion of cyclic AMP and little stimulation of excretion by PTH (increase, 0.3 +/- 0.06 mumol). Patients with primary hyperparathyroidism had high baseline cyclic AMP excretion but sub-normal stimulation by PTE (increase, 0.46 +/- 0.13); in contrast, patients with different gastrointestinal disease had high baseline excretion and supranormal stimulation of cyclic AMP excretion (increase, 5.2 +/- 0.6). We speculate that an impaired response to PTH might be involved in the slightly increased urinary calcium excretion in normocalcemic stone formers suggested by others. |
| Databáze: | OpenAIRE |
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