Targeted Delivery for Neurodegenerative Disorders Using Gene Therapy Vectors: Gene Next Therapeutic Goals
| Autor: | Geeta Swargiary, Vinayak Agarwal, Ramneek Kaur, Shriya Agarwal, Mugdha Agarwal, Surinder P. Singh, Shalini Mani, Sahil Srivastava, Sakshi Tyagi, Deepshikha Yadav, Manisha Singh |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Modern medicine
Multiple Sclerosis Genetic enhancement Genetic Vectors Disease Vectors in gene therapy Bioinformatics Viral vector Muscular Atrophy Spinal Drug Delivery Systems Retinal Diseases Alzheimer Disease Drug Discovery Genetics Humans Medicine Motor Neuron Disease Molecular Biology Genetics (clinical) Gene Editing business.industry Multiple sclerosis Amyotrophic Lateral Sclerosis Neurodegenerative Diseases Parkinson Disease Genetic Therapy Spinal muscular atrophy medicine.disease Huntington Disease Gene Expression Regulation Molecular Medicine Alzheimer's disease business |
| Zdroj: | Current Gene Therapy. 21:23-42 |
| ISSN: | 1566-5232 |
| DOI: | 10.2174/1566523220999200817164907 |
| Popis: | The technique of gene therapy, ever since its advent nearly fifty years ago, has been utilized by scientists as a potential treatment option for various disorders. This review discusses some of the major neurodegenerative diseases (NDDs) like Alzheimer’s disease (AD), Parkinson’s Disease (PD), Motor neuron diseases (MND), Spinal Muscular Atrophy (SMA), Huntington’s Disease (HD), Multiple Sclerosis (MS), etc. and their underlying genetic mechanisms along with the role that gene therapy can play in combating them. The pathogenesis and the molecular mechanisms specifying the altered gene expression of each of these NDDs have also been discussed in elaboration. The use of gene therapy vectors can prove to be an effective tool in the field of curative modern medicine for the generations to come. Therefore, consistent efforts and progressive research towards its implementation can provide us with powerful treatment options for disease conditions that have so far been considered as incurable. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|