Combined pancreaticoduodenal-kidney transplantation in rats
| Autor: | Gu Jianyun, Li Jieshou, Gu Yongping |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Duodenum Rats Inbred WF Vena Cava Inferior Iliac Vein Anastomosis Inferior vena cava Renal Veins Diabetes Mellitus Experimental medicine.artery Animals Medicine Vein Kidney transplantation Portal Vein business.industry Anastomosis Surgical Abdominal aorta medicine.disease Kidney Transplantation Rats Surgery Transplantation medicine.anatomical_structure medicine.vein Cuff cardiovascular system Pancreas Transplantation business Kidney disease |
| Zdroj: | Microsurgery. 21:55-57 |
| ISSN: | 1098-2752 0738-1085 |
| DOI: | 10.1002/micr.1009 |
| Popis: | The objective of this work was to establish a stable and simple simultaneous pancreaticoduodenal-kidney transplantation model in rats. The methods involved harvesting a pancreaticoduodenal-kidney (left) (PDK) and 1-cm inferior vena cava (IVC) with a 0.5-cm left and right iliac communis vein from donors and to "cuff" anastomose between portal vein and right iliac communis vein, left kidney vein, and left iliac communis vein, converging donor portal vein and left kidney vein into IVC together. Next, we performed an anastomosis of the donor arterial segment and recipient abdominal aorta and a "cuff" anastomosis between donor IVC and recipient left kidney vein. Of 67 transplanted rats in which diabetes was induced, 57 survived >7 days, 55 survived 1 month, 54 rats have survived >4 months. In 51 rats, nonfasting plasma glucose levels were euglycemic. We performed three "cuff" anastomoses to simplify the surgical procedure and to shorten the ischemia time of the graft; the recipient vein system has an integrated endovenous membrane to avoid venous thrombi in venous anastomosis sites. |
| Databáze: | OpenAIRE |
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