Congolese children with sickle cell trait may exhibit glomerular hyperfiltration: A case control study
| Autor: | Jean-Lambert Gini-Ehungu, Célestin N. Nsibu, Pépé Mfutu Ekulu, François B. Lepira, René M. Ngiyulu, Jean Robert R. Makulo, Nazaire M. Nseka, Michel Ntetani Aloni |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Adolescent Clinical Biochemistry Renal function 030204 cardiovascular system & hematology Gastroenterology Sickle Cell Trait 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Immunology and Allergy Humans Urea 030212 general & internal medicine Child Research Articles Body surface area Sickle cell trait Proteinuria business.industry Biochemistry (medical) Public Health Environmental and Occupational Health Case-control study Hematology medicine.disease Creatine Sickle cell anemia Uric Acid Medical Laboratory Technology Blood pressure Case-Control Studies Child Preschool Immunology Democratic Republic of the Congo Kidney Diseases medicine.symptom business Glomerular hyperfiltration |
| Popis: | Background The prevalence of sickle cell trait is extremely high in sub-Saharan Africa. Recent studies have reported the impact of sickle cell carriers on renal function. However, data on renal abnormalities in children with sickle cell trait in this part of the world are unknown. In this report, we assess the glomerular function of children with sickle cell trait (SCT). Methods A case control study was conducted to assess the glomerular function in 43 Congolese children with sickle cell trait (Hb-AS) matched for age to 65 children with sickle cell anemia in steady state (Hb-SS) and 67 normal controls (Hb-AA). Results There was a significant difference in the blood pressure levels between the Hb-AS group vs Hb-SS group (P |
| Databáze: | OpenAIRE |
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