Metamorphopsia associated with central retinal vein occlusion
| Autor: | Yuki Nakano, Yukari Takasago, Rie Osaka, Chieko Shiragami, Yuki Muraoka, Koichiro Manabe, Akitaka Tsujikawa, Kazuyuki Hirooka, Tomoyoshi Fujita |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Photoreceptors Male Visual acuity Sensory Receptors genetic structures Vision Visual Acuity lcsh:Medicine Social Sciences Diagnostic Radiology chemistry.chemical_compound 0302 clinical medicine Central retinal vein occlusion Animal Cells Medicine and Health Sciences Contrast (vision) Psychology Prospective Studies Prospective cohort study lcsh:Science Tomography media_common Neurons Aged 80 and over Multidisciplinary Radiology and Imaging Retinal detachment Middle Aged Physical Sciences Retinal Disorders Sensory Perception Female medicine.symptom Anatomy Cellular Types Tomography Optical Coherence Research Article Signal Transduction medicine.medical_specialty Ellipsoids Imaging Techniques media_common.quotation_subject Ocular Anatomy Vision Disorders Geometry Research and Analysis Methods Retina 03 medical and health sciences Ocular System Diagnostic Medicine Ophthalmology Retinal Vein Occlusion medicine Humans Metamorphopsia Macular edema Aged business.industry lcsh:R Retinal Detachment Biology and Life Sciences Afferent Neurons Retinal Vessels Retinal Cell Biology medicine.disease eye diseases 030104 developmental biology chemistry Cellular Neuroscience 030221 ophthalmology & optometry Cardiovascular Anatomy Optometry Eyes Blood Vessels lcsh:Q business Head Mathematics Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 10, p e0186737 (2017) |
| ISSN: | 1932-6203 |
| Popis: | This prospective study aimed to investigate metamorphopsia in eyes with central retinal vein occlusion (CRVO) and included 28 eyes (28 patients) with unilateral CRVO that had macular edema (ME) in the acute phase. The ME was treated with anti-vascular endothelial growth factor agents. At baseline and at 1 and 6 months after initiation of treatment, quantitative measurements of metamorphopsia were performed using M-CHARTS and the retinal morphologic changes were examined by optical coherence tomography. At baseline, metamorphopsia was detected on M-CHARTS in 14 (50.0%) eyes. The mean M-CHARTS score was 0.37 ± 0.53. At 1 month and 6 months after initiation of treatment, there was substantial resolution of ME and significant recovery of visual acuity. In contrast, metamorphopsia was still detected in 16 eyes at 6 months; the mean M-CHARTS scores were 0.29 ± 0.37 at 1 month and 0.32 ± 0.38 at 6 months, and had not significantly improved from baseline (p = 0.580, and p = 0.604, respectively). Although the M-CHARTS score at 6 months was associated with the baseline M-CHARTS score (p = 0.004), it did not have any associations with morphologic parameters at baseline. However, the M-CHARTS score at 6 months was significantly associated with foveal photoreceptor status, height of serous detachment, and parafoveal thickening at 1 month. Metamorphopsia associated with CRVO could be quantified using M-CHARTS, and often persisted in contrast with the recovery of visual acuity and resolution of ME after treatment with anti-vascular endothelial growth factor agents. |
| Databáze: | OpenAIRE |
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