Mitogenic peptides in breast cyst fluid: relationship with intracystic electrolyte ratios
| Autor: | Michael P. Schrey, K. V. Patel, M. A. Ghatei, Stephen R. Bloom, M.W. Ghilchik, V.H.T. James, Kazuhiro Takahashi, L.C. Lai |
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| Rok vydání: | 1990 |
| Předmět: |
Cancer Research
medicine.medical_specialty Mammary gland Biology Breast cysts Breast cancer Epidermal growth factor Internal medicine medicine Humans Cyst Fibrocystic Breast Disease Growth Substances Epidermal Growth Factor Endothelins Sodium Apocrine Exudates and Transudates medicine.disease Epithelium Endocrinology medicine.anatomical_structure Oncology Gastrin-Releasing Peptide Potassium Female Endothelin receptor Peptides |
| Zdroj: | International journal of cancer. 46(6) |
| ISSN: | 0020-7136 |
| Popis: | Women with palpable breast cysts which are lined with apocrine epithelium may be at higher risk of developing breast cancer than women with breast cysts which are lined with flattened epithelium, the former group being characterized by intracystic sodium to potassium ratios below 3, while the latter group has intracystic sodium to potassium ratios above 3. In this study the distribution of intracystic concentrations of the mitogenic peptides, epidermal growth factor, endothelin and gastrin-releasing peptide in the 2 groups of breast cysts were compared to see whether differences in concentrations between the 2 cyst groups might provide an explanation for the higher risk of breast cancer observed in women with "apocrine" breast cysts. The concentrations of epidermal growth factor and gastrin-releasing peptide were significantly higher in the low electrolyte ratio group (p less than 0.001). There was no difference in endothelin concentrations between the 2 groups. Negative correlations were found between epidermal growth factor concentrations and Na+/K+ and between gastrin-releasing peptide concentrations and Na+/K+ (p less than 0.001). A positive correlation was found between gastrin-releasing peptide and epidermal growth factor concentrations in breast cyst fluid (p less than 0.001). The significantly higher intracystic concentrations of both epidermal growth factor and gastrin-releasing peptide in the low-electrolyte-ratio group may provide an explanation for the higher risk of breast cancer which has been observed in women with "apocrine" breast cysts. |
| Databáze: | OpenAIRE |
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