SARS‐CoV‐2 respiratory viral loads and association with clinical and biological features

Autor: Biguenet, Adrien, Bouiller, Kévin, Marty-Quinternet, Solène, Brunel, Anne-Sophie, Chirouze, Catherine, Lepiller, Quentin, Marty‐Quinternet, Solène, Brunel, Anne‐Sophie
Přispěvatelé: Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Laboratoire Chrono-environnement (UMR 6249) (LCE), Cholley, Pascal, Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), Laboratoire Chrono-environnement - CNRS - UFC (UMR 6249) (LCE)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Fibrinogen
Gastroenterology
MESH: Virus Shedding
chemistry.chemical_compound
0302 clinical medicine
COVID-19 Testing
MESH: Aged
80 and over
Nasopharynx
Prealbumin
MESH: COVID-19
030212 general & internal medicine
Respiratory system
MESH: Treatment Outcome
Aged
80 and over
MESH: Aged
MESH: Anosmia
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
MESH: Middle Aged
viral loads
Middle Aged
Viral Load
3. Good health
Virus Shedding
Infectious Diseases
C-Reactive Protein
Treatment Outcome
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
MESH: Young Adult
MESH: Dyspnea
MESH: RNA
Viral
Biomarker (medicine)
RNA
Viral
030211 gastroenterology & hepatology
Female
France
medicine.symptom
MESH: Viral Load
Viral load
medicine.drug
Adult
medicine.medical_specialty
MESH: L-Lactate Dehydrogenase
Anosmia
03 medical and health sciences
Young Adult
Virology
Internal medicine
Lactate dehydrogenase
MESH: Prealbumin
MESH: C-Reactive Protein
medicine
Humans
MESH: SARS-CoV-2
Viral shedding
[SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology
Aged
MESH: Humans
L-Lactate Dehydrogenase
business.industry
SARS-CoV-2
MESH: COVID-19 Testing
COVID-19
MESH: Adult
Confidence interval
MESH: Male
MESH: Nasopharynx
MESH: France
Dyspnea
chemistry
inflammation
MESH: Fibrinogen
business
MESH: Female
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: Journal of Medical Virology
Journal of Medical Virology, Wiley-Blackwell, 2021, 93 (3), pp.1761-1765. ⟨10.1002/jmv.26489⟩
Journal of Medical Virology, 2021, 93 (3), pp.1761-1765. ⟨10.1002/jmv.26489⟩
Journal of Medical Virology, Wiley-Blackwell, 2020, ⟨10.1002/jmv.26489⟩
ISSN: 0146-6615
1096-9071
DOI: 10.1002/jmv.26489⟩
Popis: International audience; To determine the distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) respiratory viral loads (VL) during the acute phase of infection and their correlation with clinical presentation and inflammation-related biomarkers. Nasopharyngeal swabs from 453 adult SARS-CoV-2-infected patients from the Department of Infectious Diseases, Besançon, France, were collected at the time of admission or consultation for reverse transcriptase polymerase chain reaction (RT-PCR) analysis. Clinical information and concentrations of biological parameters (C-reactive protein [CRP], fibrinogen, lactate dehydrogenase [LDH], prealbumin) were noticed. Mean respiratory VL homogeneously decreased from 7.2 log10 copies/ml (95% confidence interval [CI]: 6.6-7.8) on the first day of symptoms until 4.6 log10 copies/ml (95% CI: 3.8-5.4) at day 10 (slope = -0.24; R2 = .95). VL were poorly correlated with COVID-19 symptoms and outcome, excepted for dyspnea and anosmia, which were significantly associated with lower VL (p
Databáze: OpenAIRE
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