Denhaminols A–H, Dihydro-β-agarofurans from the Endemic Australian Rainforest Plant Denhamia celastroides
| Autor: | Peter Conrad Healy, Colleen C. Nelson, Rohan A. Davis, Claire Levrier, Martin C. Sadowski |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Rainforest Stereochemistry Molecular Conformation Pharmaceutical Science Pharmacology Biology Crystallography X-Ray Analytical Chemistry Drug Discovery LNCaP Humans Cytotoxic T cell Molecular Structure Organic Chemistry Australia Absolute configuration Celastraceae Antineoplastic Agents Phytogenic Denhamia celastroides Plant Leaves Complementary and alternative medicine Lipid content Molecular Medicine Drug Screening Assays Antitumor Cancer cell lines Sesquiterpenes Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Journal of Natural Products. 78:111-119 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | Eight new dihydro-β-agarofurans, denhaminols A-H (1-8), were isolated from the leaves of the Australian rainforest tree Denhamia celastroides. The chemical structures of 1-8 were elucidated following analysis of 1D/2D NMR and MS data. The absolute configuration of denhaminol A (1) was determined by single-crystal X-ray crystallography. All compounds were evaluated for cytotoxic activity against the human prostate cancer cell line LNCaP, using live-cell imaging and metabolic assays. Denhaminols A (1) and G (7) were also tested for their effects on the lipid content of LNCaP cells. This is the first report of secondary metabolites from D. celastroides. |
| Databáze: | OpenAIRE |
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