Pancreatic cancer risk and nutrition-related methyl-group availability indicators in male smokers
| Autor: | P R Taylor, Rachael Z. Stolzenberg-Solomon, T. J. Hartman, Jarmo Virtamo, Demetrius Albanes, Rautalahti M, Joseph A. Tangrea, Sehlub J, Nieto Fj |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Risk Cancer Research medicine.medical_specialty Pancreatic disease Methylation Folic Acid Pancreatic cancer Internal medicine Vegetables medicine Biomarkers Tumor Odds Ratio Humans Risk factor Homocysteine Aged Cancer prevention business.industry Smoking Cancer Pyridoxine Odds ratio Middle Aged medicine.disease Pancreatic Neoplasms Vitamin B 12 Endocrinology Logistic Models Oncology Case-Control Studies Fruit Cohort Exocrine pancreatic cancer business |
| Zdroj: | Journal of the National Cancer Institute. 91(6) |
| ISSN: | 0027-8874 |
| Popis: | BACKGROUND Few risk factors for pancreatic cancer have been identified, with age and cigarette smoking being the most consistent. The protective effect associated with consumption of fruits and vegetables-the major dietary sources of folate-is suggestive of a role for factors influencing cellular methylation reactions; however, to our knowledge, no study has investigated this relationship. Whether biochemical indicators of methyl-group availability are associated with exocrine pancreatic cancer risk was the focus of this investigation. METHODS We conducted a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of 29133 male Finnish smokers aged 50-69 years. One hundred twenty-six subjects with incident exocrine pancreatic cancer were matched by date of baseline blood draw (+/-30 days), study center, age (+/-5 years), trial intervention group, and completion of dietary history to 247 control subjects, who were alive and free from cancer at the time the case subjects were diagnosed. Odds ratios (ORs) and 95% confidence intervals (CIs) were determined by use of conditional logistic regression. Reported P values are two-tailed. RESULTS Serum folate and pyridoxal-5'-phosphate (PLP) concentrations showed statistically significant inverse dose-response relationships with pancreatic cancer risk, with the highest serum tertiles having approximately half the risk of the lowest (folate: OR = 0.45; 95% CI = 0.24-0.82; P for trend = .009, and PLP: OR = 0.48; 95% CI = 0.26-0.88; P for trend = .02). An increased pancreatic cancer risk was also observed with greater exposure to cigarettes (e.g., pack-years [number of packs smoked per day x number of years of smoking], highest versus lowest quartile: OR = 2.13; 95% CI = 1.13-3.99; P for trend = .04). CONCLUSIONS These results support the hypothesis that maintaining adequate folate and pyridoxine status may reduce the risk of pancreatic cancer and confirm the risk previously associated with cigarette smoking. |
| Databáze: | OpenAIRE |
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