An assessment of sympathetic function in isolated tissues from mice given nerve-growth-factor antiserum and 6-hydroxydopamine
| Autor: | Barbara Kneen, Jennifer A. Kirk, B. J. Large, I. E. Hughes |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Chronotropic
Male medicine.medical_specialty Sympathetic nervous system animal structures Sympathetic Nervous System medicine.medical_treatment Ileum Mice Inbred Strains Autopharmacology Biology In Vitro Techniques Fluorescence Hydroxydopamines Mice Norepinephrine Vas Deferens Heart Rate Internal medicine medicine Animals Heart Atria Nerve Growth Factors Pharmacology Hydroxydopamine Histocytochemistry Immune Sera Electric Stimulation Intestines Atropine Nerve growth factor Endocrinology medicine.anatomical_structure Sympathectomy nervous system Cholinergic medicine.drug |
| Zdroj: | British journal of pharmacology. 47(4) |
| ISSN: | 0007-1188 |
| Popis: | 1. Experiments were done on isolated tissues from mice injected with 0·9% w/v NaCl solution (saline), 6-hydroxydopamine (6-OHDA), nerve-growth-factor antiserum (NGF-As) or a combination of these agents (NGF-As+6-OHDA). 2. Fluorescence histochemistry of vasa deferentia showed clear differences between each of the treatments but no such distinction was possible in cardiac ventricle or intestine. 3. Compared with controls, the chronotropic responses of atria to field stimulation were reduced by all three treatments in the order NGF-As |
| Databáze: | OpenAIRE |
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