Determination of Fexofenadine in Tablets by Capillary Electrophoresis in Free Solution and in Solution with Cyclodextrins as Analyte Carriers

Autor:	Peter Mikuš, Emil Havránek, Iva Valášková
Rok vydání:	2005
Předmět:	Pharmacology chemistry.chemical_classification Drug Carriers Analyte Chromatography Cyclodextrin Chemistry Pharmaceutical beta-Cyclodextrins Organic Chemistry Cationic polymerization Electrophoresis Capillary Pharmaceutical Science Dosage form Inclusion compound Electrolytes chemistry.chemical_compound Capillary electrophoresis chemistry Anti-Allergic Agents Drug Discovery Histamine H1 Antagonists Terfenadine Counterion Quantitative analysis (chemistry) Tablets
Zdroj:	Drug Development and Industrial Pharmacy. 31:795-801
ISSN:	1520-5762 0363-9045
DOI:	10.1080/03639040500217368
Popis:	Capillary electrophoresis (CE) methods for the determination of fexofenadine (FEX) in commercial pharmaceuticals were developed. It was demonstrated that FEX could be effectively analyzed in free solution cationic CE at low pH. Another analytical approach studied was based on cyclodextrin (CD) modified CE where highly charged CD derivatives served as analyte carriers. In this way, the separation range was spread to physiological pH region and a CE analysis of FEX, present actually in its zwitterionic form, could be accomplished. Several parameters affecting the separations were studied, including the type and concentration of carrier ion, counterion, analyte carrier, and pH of the buffer. The methods based on the free solution CE and CD-modified CE were compared each other, validated, and applied for the determination of FEX in tablets.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd85088b446543477a3f408d6d3ece3 https://doi.org/10.1080/03639040500217368 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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