Aqueous Partition of Methanolic Extract of Dicranopteris linearis Leaves Protects against Liver Damage Induced by Paracetamol
| Autor: | Nurliana Nasir, Zainul Amiruddin Zakaria, Mohd Zaki Salleh, Farah Hidayah Kamisan, Lay Kek Teh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Antioxidant Bilirubin medicine.medical_treatment hepatoprotective free radical scavenging activity Terpene Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine endogenous antioxidant enzymes saponins triterpenes medicine Nutrition and Dietetics Traditional medicine biology Chemistry biology.organism_classification Malondialdehyde 030104 developmental biology Phytochemical Catalase 030220 oncology & carcinogenesis Dicranopteris linearis biology.protein Food Science phenolic derivatives |
| Zdroj: | Nutrients Volume 11 Issue 12 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu11122945 |
| Popis: | This study aimed to determine the antioxidant and hepatoprotective activities of semi-purified aqueous partition obtained from the methanol extract of Dicranopteris linearis (AQDL) leaves against paracetamol (PCM)-induced liver intoxication in rats. The test solutions, AQDL (50, 250, and 500 mg/kg), were administered orally to rats (n = 6) once daily for seven consecutive days followed by the hepatotoxicity induction using 3 g/kg PCM (p.o.). Blood was collected for serum biochemical parameters analysis while the liver was collected for histopathological examination and endogenous antioxidant enzymes analysis. AQDL was also subjected to antioxidant determination and phytochemical analysis. Results obtained show that AQDL possessed high total phenolic content (TPC) value and remarkable radical scavenging activities. AQDL also significantly (p < 0.05) reduced the liver weight/body weight (LW/BW) ratio or serum level of ALT, AST, and total bilirubin while significantly (p < 0.05) increase the level of superoxide dismutase (SOD) and catalase (CAT) without affecting the malondialdehyde (MDA) in the liver indicating its hepatoprotective effect. Phytoconstituents analyses showed only the presence of saponins and triterpenes, but lack of flavonoids. In conclusion, AQDL exerts hepatoprotective activity via its high antioxidant potential and ability to modulate the endogenous enzymatic antioxidant defense system possibly via the synergistic action of saponins and triterpenes. |
| Databáze: | OpenAIRE |
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