Prognostic significance of inflammatory indices in hepatocellular carcinoma treated with transarterial chemoembolization: A systematic review and meta-analysis

Autor: Guodong Cao, Shuangshuang Li, Qianhui Wang, Ling Wang, Xudong Feng
Rok vydání: 2020
Předmět:
Cancer Treatment
Pathology and Laboratory Medicine
Gastroenterology
Geographical Locations
White Blood Cells
Mathematical and Statistical Techniques
0302 clinical medicine
Animal Cells
Medicine and Health Sciences
Lymphocytes
Immune Response
Multidisciplinary
Liver Diseases
Liver Neoplasms
Statistics
Hazard ratio
Arteries
Metaanalysis
Prognosis
Oncology
030220 oncology & carcinogenesis
Meta-analysis
Hepatocellular carcinoma
Physical Sciences
Medicine
030211 gastroenterology & hepatology
Cellular Types
Research Article
China
medicine.medical_specialty
Poor prognosis
Carcinoma
Hepatocellular
Asia
Science
Inflammatory Diseases
Immune Cells
Immunology
MEDLINE
Gastroenterology and Hepatology
Research and Analysis Methods
Carcinomas
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Internal medicine
Gastrointestinal Tumors
medicine
Carcinoma
Humans
Chemoembolization
Therapeutic
Statistical Methods
Inflammation
Blood Cells
business.industry
Cancers and Neoplasms
Biology and Life Sciences
Hepatocellular Carcinoma
Cell Biology
Odds ratio
medicine.disease
Confidence interval
People and Places
business
Mathematics
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0230879 (2020)
ISSN: 1932-6203
Popis: ObjectivesTo investigate the association between inflammatory indices and clinical outcomes of hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE) by performing meta-analysis.MethodsA systematic literature search for relevant studies published up to August 2019 was performed by using PubMed, Web of Science, EMBASE, China National Knowledge Internet (CNKI) and Wanfang databases. Pooled hazard ratios (HR) or odds ratio (OR) and 95% confidence intervals (95% CI) were calculated.ResultsA total of 5280 patients from 22 studies were finally enrolled in the meta-analysis. The results demonstrated that elevated preoperative NLR, PLR, and CRP was associated with poor OS in HCC patients treated by TACE (HR = 1.81, P3 cm (OR = 2.42, P = 0.005).ConclusionsElevated preoperative NLR, PLR, and CRP are associated with poor prognosis in HCC patients treated with TACE. These inflammatory indices may be convenient, accessible, affordable and dependable biomarkers with prognostic potential for HCC patients treated by TACE.
Databáze: OpenAIRE
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