Prognostic significance of inflammatory indices in hepatocellular carcinoma treated with transarterial chemoembolization: A systematic review and meta-analysis
Autor: | Guodong Cao, Shuangshuang Li, Qianhui Wang, Ling Wang, Xudong Feng |
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Rok vydání: | 2020 |
Předmět: |
Cancer Treatment
Pathology and Laboratory Medicine Gastroenterology Geographical Locations White Blood Cells Mathematical and Statistical Techniques 0302 clinical medicine Animal Cells Medicine and Health Sciences Lymphocytes Immune Response Multidisciplinary Liver Diseases Liver Neoplasms Statistics Hazard ratio Arteries Metaanalysis Prognosis Oncology 030220 oncology & carcinogenesis Meta-analysis Hepatocellular carcinoma Physical Sciences Medicine 030211 gastroenterology & hepatology Cellular Types Research Article China medicine.medical_specialty Poor prognosis Carcinoma Hepatocellular Asia Science Inflammatory Diseases Immune Cells Immunology MEDLINE Gastroenterology and Hepatology Research and Analysis Methods Carcinomas 03 medical and health sciences Signs and Symptoms Diagnostic Medicine Internal medicine Gastrointestinal Tumors medicine Carcinoma Humans Chemoembolization Therapeutic Statistical Methods Inflammation Blood Cells business.industry Cancers and Neoplasms Biology and Life Sciences Hepatocellular Carcinoma Cell Biology Odds ratio medicine.disease Confidence interval People and Places business Mathematics |
Zdroj: | PLoS ONE PLoS ONE, Vol 15, Iss 3, p e0230879 (2020) |
ISSN: | 1932-6203 |
Popis: | ObjectivesTo investigate the association between inflammatory indices and clinical outcomes of hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE) by performing meta-analysis.MethodsA systematic literature search for relevant studies published up to August 2019 was performed by using PubMed, Web of Science, EMBASE, China National Knowledge Internet (CNKI) and Wanfang databases. Pooled hazard ratios (HR) or odds ratio (OR) and 95% confidence intervals (95% CI) were calculated.ResultsA total of 5280 patients from 22 studies were finally enrolled in the meta-analysis. The results demonstrated that elevated preoperative NLR, PLR, and CRP was associated with poor OS in HCC patients treated by TACE (HR = 1.81, P3 cm (OR = 2.42, P = 0.005).ConclusionsElevated preoperative NLR, PLR, and CRP are associated with poor prognosis in HCC patients treated with TACE. These inflammatory indices may be convenient, accessible, affordable and dependable biomarkers with prognostic potential for HCC patients treated by TACE. |
Databáze: | OpenAIRE |
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