Effects of teriparatide versus alendronate for treatment of postmenopausal osteoporosis: A meta-analysis of randomized controlled trials
| Autor: | Wei Song, Ren-Qi Jiang, Wang Yakang, Yumin Zhang, Tao Ma, Guo Jianbin, Kun Li, Siqing Qin |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Osteoporosis MEDLINE Comparative safety Postmenopausal osteoporosis law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Teriparatide Humans 030212 general & internal medicine Osteoporosis Postmenopausal Randomized Controlled Trials as Topic teriparatide postmenopausal Alendronate Bone Density Conservation Agents business.industry General Medicine medicine.disease osteoporosis meta-analysis Meta-analysis business 030217 neurology & neurosurgery Systematic Review and Meta-Analysis medicine.drug Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Objectives: Osteoporosis remains a clinical challenge. Teriparatide is an anabolic drug and alendronate is an antiresorptive agent; both are used in the treatment of osteoporosis. Comprehensive reviews investigating the comparative safety and efficacy of teriparatide versus alendronate are scarce. Therefore, we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the safety and efficacy of teriparatide versus alendronate for the treatment of postmenopausal osteoporosis. Methods: We conducted a comprehensive literature review of the PubMed, EMBASE, Cochrane Controlled Trials Registry, and the China Academic Journal Network Publishing databases for relevant RCTs of teriparatide versus alendronate in postmenopausal osteoporosis patients. Outcome measures were percentage change in lumbar spine and femoral neck bone mineral density (BMD) and incidence of vertebral and nonvertebral fractures. Effect size was reported as weighted mean differences (WMDs) for continuous outcomes and odds ratios (OR) for dichotomous outcomes, with associated 95% confidence intervals (CIs). Results: Six trials involving 618 patients were included. The meta-analysis demonstrated a significant increase in lumbar spine BMD (WMD: 3.46, 95% CI: 2.15–4.77, P |
| Databáze: | OpenAIRE |
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