Multi-regulatory network of ROS: the interconnection of ROS, PGC-1 alpha, and AMPK-SIRT1 during exercise
| Autor: | Cláudio T. De Souza, Anand Thirupathi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Antioxidant Physiology medicine.medical_treatment Energy metabolism Alpha (ethology) Physical exercise Biology Nitric Oxide Biochemistry 03 medical and health sciences 0302 clinical medicine Sirtuin 1 medicine Animals Humans Exercise Transcription factor chemistry.chemical_classification Reactive oxygen species Adenylate Kinase food and beverages AMPK General Medicine Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Cell biology 030104 developmental biology chemistry Mitochondrial biogenesis Energy Metabolism Reactive Oxygen Species 030217 neurology & neurosurgery |
| Zdroj: | Journal of Physiology and Biochemistry. 73:487-494 |
| ISSN: | 1877-8755 1138-7548 |
| Popis: | Transcriptional factors are easily susceptible to any stimuli, including exercise. Exercise can significantly influence PGC-1 α and AMPK-SIRT1 pathway, as it is involved in the regulation of energy metabolism and mitochondrial biogenesis. Exercise is a major energy deprivation process by which many of transcription factors get tuned positively. However, how transcription factors help to boost the antioxidant defense system at cellular level is elusive. It is well known that physical exercise can induce reactive oxygen species, but how these reactive oxygen species can help to regulate multiple transcription factors during exercise is an important area to be discussed yet. This review mainly focuses on interconnecting role of PGC-1 α and AMPK-SIRT1 pathway during exercise and how these proteins are getting tuned by reactive oxygen species in exercise condition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink