RapidBrachyMCTPS: a Monte Carlo-based treatment planning system for brachytherapy applications
| Autor: | Shirin A. Enger, Jan Seuntjens, Michael D.C. Evans, Christopher Poole, Gabriel Famulari, Marc-André Renaud |
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| Rok vydání: | 2018 |
| Předmět: |
Computer science
medicine.medical_treatment Monte Carlo method Brachytherapy computer.software_genre Imaging phantom 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Prostate Voxel medicine Dosimetry Humans Radiology Nuclear Medicine and imaging Radiation treatment planning Simulation Radiological and Ultrasound Technology Phantoms Imaging Radiotherapy Planning Computer-Assisted Radiotherapy Dosage Gold standard (test) medicine.anatomical_structure 030220 oncology & carcinogenesis Benchmark (computing) Dose rate computer Monte Carlo Method Software |
| Zdroj: | Physics in medicine and biology. 63(17) |
| ISSN: | 1361-6560 |
| Popis: | Despite being considered the gold standard for brachytherapy dosimetry, Monte Carlo (MC) has yet to be implemented into a software for brachytherapy treatment planning. The purpose of this work is to present RapidBrachyMCTPS, a novel treatment planning system (TPS) for brachytherapy applications equipped with a graphical user interface (GUI), optimization tools and a Geant4-based MC dose calculation engine, RapidBrachyMC. Brachytherapy sources and applicators were implemented in RapidBrachyMC and made available to the user via a source and applicator library in the GUI. To benchmark RapidBrachyMC, TG-43 parameters were calculated for the microSelectron v2 (192Ir) and SelectSeed (125I) source models and were compared against previously validated MC brachytherapy codes. The performance of RapidBrachyMC was evaluated for a prostate high dose rate case. To assess the accuracy of RapidBrachyMC in a heterogeneous setup, dose distributions with a cylindrical shielded/unshielded applicator were validated against film measurements in a Solid WaterTM phantom. TG-43 parameters calculated using RapidBrachyMC generally agreed within 1%-2% of the results obtained in previously published work. For the prostate case, clinical dosimetric indices showed general agreement with Oncentra TPS within 1%. Simulation times were on the order of minutes on a single core to achieve uncertainties below 2% in voxels within the prostate. The calculation time was decreased further using the multithreading features of Geant4. In the comparison between MC-calculated and film-measured dose distributions, at least 95% of points passed the 3%/3 mm gamma index criteria in all but one case. RapidBrachyMCTPS can be used as a post-implant dosimetry toolkit, as well as for MC-based brachytherapy treatment planning. This software is especially well suited for the development of new source and applicator models. |
| Databáze: | OpenAIRE |
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