Fabrication of Chitosan-Reinforced Multifunctional Graphene Nanocomposite as Antibacterial Scaffolds for Hemorrhage Control and Wound-Healing Application
| Autor: | Baskaran Ramalingam, Priyadarshani Choudhary, Sujoy K. Das |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Silver
0206 medical engineering Biomedical Engineering Metal Nanoparticles Hemorrhage 02 engineering and technology Silver nanoparticle law.invention Nanocomposites Biomaterials Chitosan chemistry.chemical_compound Anti-Infective Agents law Humans Nanocomposite Graphene Biomaterial 021001 nanoscience & nanotechnology 020601 biomedical engineering Anti-Bacterial Agents chemistry Clotting time Chemical engineering Graphite 0210 nano-technology Antibacterial activity Wound healing |
| Zdroj: | ACS biomaterials scienceengineering. 6(10) |
| ISSN: | 2373-9878 |
| Popis: | Accidents on battlefields and roads often lead to hemorrhage and uncontrolled bleeding. Hence, immediate hemorrhage control remains of great importance to reduce mortality and socioeconomic loss. Herein, nanobiocomposite scaffolds (film and sponge) have been fabricated for the first time through the incorporation of a graphene-silver-polycationic peptide (GAP) nanocomposite into chitosan (Cs). Ten different scaffolds viz. Cs, Cs-GAP25, Cs-GAP50, Cs-GAP75, and Cs-GAP100 were prepared in the form of films and sponges. Cs-GAP100 nanobiocomposite sponge exhibited excellent porosity, fluid absorption, and blood clotting capacity, whereas Cs-GAP100 nanobiocomposite film showed excellent mechanical strength and poor degradation property. The presence of graphene in GAP provided a unique mechanical property and prevented the natural degradation, whereas silver nanoparticles and polycationic peptide provided an efficient antimicrobial property to the scaffolds. The high surface area of graphene and the hydrophilic nature of the polycationic peptide also imparted high fluid and blood absorption capacity to Cs-GAP nanobiocomposite scaffolds. The in vitro whole blood clotting assay demonstrated that clotting efficacy improved with the concentration of GAP nanocomposite and Cs-GAP100 nanobiocomposite sponge significantly (p value |
| Databáze: | OpenAIRE |
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