Skin absorption through atopic dermatitis skin: a systematic review
| Autor: | H. I. Maibach, Ivone Jakasa, A.-S. Halling-Overgaard, K.A. Engebretsen, Jacob P. Thyssen, Sanja Kezic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Skin barrier medicine.medical_specialty Adolescent Skin Absorption Dermatology Dermatitis Atopic Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Animals Humans In patient Child Skin absorption atopic dermatitis systemic exposure to chemicals Chemical Ingredients Human studies business.industry Atopic dermatitis Middle Aged medicine.disease Disease Models Animal 030104 developmental biology Contact allergy Female Animal studies business |
| Zdroj: | British journal of dermatology. 177(1):84-106 |
| ISSN: | 0007-0963 |
| DOI: | 10.1111/bjd.15065 |
| Popis: | Patients with atopic dermatitis (AD) have skin barrier impairment in both lesional and nonlesional skin. They are typically exposed daily to emollients and intermittently to topical anti-inflammatory medicaments, thereby increasing the risk of developing contact allergy and systemic exposure to chemical ingredients found in these topical preparations. We systematically searched for studies that investigated skin absorption of various penetrants, including medicaments, in patients with AD, but also in animals with experimentally-induced dermatitis. We identified 40 articles: 11 human studies examining model penetrants, 26 human studies examining AD drugs, and three animal studies. We conclude that patients with AD have almost twofold increased skin absorption compared with healthy controls. There is a need for well-designed epidemiological and dermatopharmacokinetic studies that examine to what extent AD causes patients to be systemically exposed to chemicals compared with nonatopic dermatitis. |
| Databáze: | OpenAIRE |
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