A Population-based Case-control Teratological Study of Oral Nystatin Treatment During Pregnancy

Autor: Elisabeth Puho, Andrew E. Czeizel, Zoltán Kazy
Rok vydání: 2003
Předmět:
Male
Nystatin
Administration
Oral
Pregnancy
Reference Values
Oral administration
Oral nystatin
Odds Ratio
Birth Weight
Registries
Pregnancy Complications
Infectious
Hypospadias
education.field_of_study
Obstetrics
Incidence
Pregnancy Outcome
Abnormalities
Drug-Induced
General Medicine
humanities
Teratogens
Infectious Diseases
embryonic structures
Gestation
Female
Infant
Premature
medicine.drug
Adult
Microbiology (medical)
medicine.medical_specialty
animal structures
Population
Gestational Age
Population based
Risk Assessment
Drug Administration Schedule
Confidence Intervals
medicine
Humans
education
Probability
Gynecology
Dose-Response Relationship
Drug
General Immunology and Microbiology
business.industry
Infant
Newborn
Case-control study
medicine.disease
Case-Control Studies
business
Follow-Up Studies
Zdroj: Scandinavian Journal of Infectious Diseases. 35:830-835
ISSN: 1651-1980
0036-5548
DOI: 10.1080/00365540310017069
Popis: The aim of the study was to investigate the teratogenicity of oral nystatin treatment during pregnancy in the population-based data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities between 1980 and 1996. In total, 38,151 pregnant women who delivered newborn infants without any defects (control group) and 22,843 pregnant women who had foetuses or newborns with congenital abnormalities (CA) (case group) were included in the study. 106 (0.5%) case and 143 (0.4%) control pregnant women were treated with oral nystatin (crude OR with 95% CI = 1.2, 1.0-1.6). A teratogenic potential of nystatin was seen in 1 CA-group (hypospadias) in 2 different approaches of the study (case-control and total control--CA groups comparison) during the critical period of this congenital abnormality. The conclusion of the study is that treatment with oral nystatin during pregnancy presents little teratogenic risk to the foetus, but the possible association between hypospadias and nystatin needs further study.
Databáze: OpenAIRE
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