| Autor: |
Monte M. Winslow, Amato J. Giaccia, Albert C. Koong, Philippe Mourrain, Grace E. Kim, Edward E. Graves, Laura Castellini, Margaret Kozak, Pauline Chu, Dedeepya Vaka, Rosanna K. Ma, Arwa S. Kathiria, Barbara M. Grüner, Dian Yang, Gordon X. Wang, Viviana I. Risca, Shin-Heng Chiou |
| Rok vydání: |
2023 |
| DOI: |
10.1158/2159-8290.22531571.v1 |
| Popis: |
Supplementary Figure S1. Isolation of the Hmga2-GFPpos PDAC sub-population from the KPCcolors mice and GFPpos PDAC cells are a highly metastatic state;Supplementary Figure S2. Highly metastatic PDAC cells have a gene signature that is not enriched for CSC markers and distal PDAC metastases reveal minor gene expression changes related to glucose metabolism;Supplementary Figure S3. Identification of top candidate pro-metastatic genes and interrogation of Blimp1 function in PDAC metastasis;Supplementary Figure S4. Hmga2positive PDAC areas overlap with hypoxic areas and Hmga2 protein is slightly induced by hypoxia but not critical to the expression of hypoxia-induced target genes;Supplementary Figure S5. Hypoxia-induced Blimp1 expression is linked to functional HRE motifs 240 kb upstream of its transcription start site;Supplementary Figure S6. Blimp1 may contribute to migratory and clonal growth ability and is critical for a subset of hypoxia-induced gene expression changes that are independent of changes in chromatin accessibility;Supplementary Figure S7. Blimp1 regulates a subset of hypoxia-induced genes; Supplementary Figure S8. Blimp1 is required for hypoxia-induced cell cycle arrest and the expression of metastasis modulators. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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