The BOLD signal and neurovascular coupling in autism
| Autor: | Julia J. Harris, Clare Reynell |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
genetic structures Autism Electroencephalography 0302 clinical medicine Premovement neuronal activity Neurons 0303 health sciences Blood-oxygen-level dependent Energy medicine.diagnostic_test Brain Blood flow Magnetic Resonance Imaging Vasodilation Cerebrovascular Circulation Female Glutamate Psychology Neurovascular coupling psychological phenomena and processes Selective Serotonin Reuptake Inhibitors Serotonin Cognitive Neuroscience behavioral disciplines and activities Article 03 medical and health sciences Interneurons mental disorders medicine Animals Humans BOLD fMRI Autistic Disorder 030304 developmental biology Neurophysiology Neurovascular bundle medicine.disease Oxygen Disease Models Animal Glucose nervous system Vasoconstriction ComputingMilieux_COMPUTERSANDSOCIETY Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Developmental Cognitive Neuroscience |
| ISSN: | 1878-9307 1878-9293 |
| Popis: | Highlights • Neurovascular coupling and energy use may be changed in autism. • The relationship between neural activity and the BOLD signal may be altered in autism. • Simply comparing the BOLD signal of control and autistic people may not be meaningful. • Combined techniques will aid the interpretation of group differences in the BOLD signal. BOLD (blood oxygen level dependent) fMRI (functional magnetic resonance imaging) is commonly used to study differences in neuronal activity between human populations. As the BOLD response is an indirect measure of neuronal activity, meaningful interpretation of differences in BOLD responses between groups relies upon a stable relationship existing between neuronal activity and the BOLD response across these groups. However, this relationship can be altered by changes in neurovascular coupling or energy consumption, which would lead to problems in identifying differences in neuronal activity. In this review, we focus on fMRI studies of people with autism, and comparisons that are made of their BOLD responses with those of control groups. We examine neurophysiological differences in autism that may alter neurovascular coupling or energy use, discuss recent studies that have used fMRI to identify differences between participants with autism and control participants, and explore experimental approaches that could help attribute between-group differences in BOLD signals to either neuronal or neurovascular factors. |
| Databáze: | OpenAIRE |
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