Dengue Research Funded by the European Commission-Scientific Strategies of Three European Dengue Research Consortia
| Autor: | Axel Kroeger, Fernando Augusto Bozza, Gavin Screaton, Peter Byass, Joacim Rocklöv, Bernard Cazelles, Marco Vignuzzi, Simon Hay, Annelies Wilder-Smith, Bridget Wills, Kerstin Rosenberger, Jeremy Farrar, Gabriela Maron, Adriana Tami, Michael Schreiber, Ernesto T A Marques, Andrea Caprara, Eric Daudé |
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| Přispěvatelé: | Section Clinical Tropical Medicine [Heidelberg], Department of Infectious Diseases [Heidelberg, Germany], Heidelberg University Hospital [Heidelberg]-Heidelberg University Hospital [Heidelberg], Génétique fonctionnelle des Maladies infectieuses - Functional Genetics of Infectious Diseases, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Department of Public Health and Clinical Medicine, Umeå University, This work was supported by the IDAMS project (European Union 7th FP, grant 281803), the DENFREE project (European Union 7th FP, grant 282378), and the DengueTools project (European Union 7th FP, grant 282589)., IDAMS - International Research Consortium on Dengue Risk Assessment, Management, and Surveillance : Thomas Jaenisch, Thomas Junghanss, Kerstin Rosenberger, Jaswinder Kaur (Section Clinical Tropical Medicine, Heidelberg Universty Hospital), Simon Hay, Janey Messina, Adrian Hill (Oxford University), Bridget Wills, Cameron Simmons, Marcel Wolbers, Jeremy Farrar (Oxford University Clinical Research Unit, Vietnam), Phil McCall (Liverpool School of Tropical Medicine), Antonio Lanzavecchia, Federica Sallusto (Institute for Research in Biomedicine, Bellinzona, Switzerland), Axel Kroeger, Silvia Runge-Ranzinger (TDR-WHO), Lucy Lum (University of Malaya Medical Center), Ida Safitri (Gadja Madah University, Indonesia), Varun Kumar (Angkor Hospital for Children, Cambodia), Maria Guzman (Instituto Pedro Kouri, Cuba), Gabriela Maron, Ernesto Pleitess (Hospital National de Ninos Benjamin Bloom, San Salvador), Andrea Caprara, Bruno Benevides (State University of Ceara, Brazil), Willy Wint (Environmental Research Group Oxford Ltd.), Osman Sankoh (INDEPTH-Network, Ghana), Fleur Monasso (Red Cross/Red Crescent Climate Centre, The Netherlands), Adriana Tami (University of Carabobo, Venezuela), Ernesto T. A. Marques, Fernando A. Bozza (FIOCRUZ, Brazil), DENFREE - Dengue Research Framework for Resisting Epidemics in Europe : Anavaj Sakuntabhai, Richard Paul, Félix Rey, Anna-Bella Failloux, Marco Vignuzzi, Louis Lambrechts (Institut Pasteur, France), Gavin Screaton, Juthathip Mongkolsapaya (Imperial College, United Kingdom), Michael Schreiber, Rolf Horstmann (Bernard Nocht Institute, Germany), Pattamaporn Kittayapong, Pratap Singhasivanon, Sutee Yoksan (Mahidol University, Thailand), Philippe Buchy, Vincent Deubel (Institut Pasteur Cambodia, Cambodia), Xavier Rodó (Fundacio Institut Catala De Ciencies Del Clima, Spain), Eric Daude, Alain Vaguet (University of Rouen, France), Bernard Cazelles (CNRS, France), Nico Stollenwerk (Cmaf, Fundacao Da Faculdade De Ciencias Da Universidade De Lisboa, Portugal), Luísa Pereira (Instituto De Patologia E Imunologia Molecular Da Universidade Do Porto, Portugal), Timo Kanninen (Biocomputing Platforms Ltd Oy, Finland), Guido Krupp (Amptec Gmbh, Germany), Mark Thursz (Riotech Pharmaceticals Ltd, United Kingdom), María G. Guzmán (Instituto Pedro Kouri, Cuba), DengueTools - Innovative Tools and Strategies for the Surveillance and Control of Dengue : Annelies Wilder-Smith, Joacim Rocklöv, Peter Byass (Umeå University, Sweden), Paba Palihawadana, Hasitha Tissera (Epidemiological Unit, Ministry of Health, Sri Lanka), David Brooks (TwistDx Ltd, UK), Sazaly Abu Bakar (University of Malaya), Luke Alphey (Oxitec Ltd, UK), Pattamaporn Kittayapong (Mahidol University, Thailand), Steve Lindsay, James Logan (London School of Hygiene and Tropical Medicine, UK), Christoph Hatz, Andreas Neumayr (Swiss Tropical and Public Health Institute), Paul Reiter (Institut Pasteur, France), Yesim Tozan, Valérie R. Louis (Heidelberg University Hospital), Duane Gubler (Duke-NUS Graduate Medical School Singapore), Eduardo Massad (University of Sao Paolo), Antonio Tenorio (Instituto de Salud Carlos III), Christophe Lagneau, Grégory L'Ambert (Entente Inter-Départementale pour la Démoustication du littoral Mediterranéen), European Project: 281803,EC:FP7:HEALTH,FP7-HEALTH-2011-single-stage,IDAMS(2011), European Project: 282378,EC:FP7:HEALTH,FP7-HEALTH-2011-single-stage,DENFREE(2012), European Project: 282589,EC:FP7:HEALTH,FP7-HEALTH-2011-single-stage,DENGUETOOLS(2011), Microbes in Health and Disease (MHD), Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Medical Research Council (MRC) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Economic growth
Biomedical Research Infektionsmedicin MESH: Dengue/prevention & control Dengue virus medicine.disease_cause Dengue fever Capital Financing Dengue IDAMS 0302 clinical medicine DENFREE 030212 general & internal medicine Chikungunya MESH: Capital Financing GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) media_common Disease surveillance education.field_of_study lcsh:Public aspects of medicine Health Policy Public Health Global Health Social Medicine and Epidemiology 11 Medical And Health Sciences 3. Good health [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Infectious Diseases ComputingMethodologies_DOCUMENTANDTEXTPROCESSING epidemiology MESH: Health Policy DengueTools Infectious Medicine lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 030231 tropical medicine Population MESH: Dengue/epidemiology Biology 03 medical and health sciences Tropical Medicine MESH: Biomedical Research/trends MESH: European Union medicine media_common.cataloged_instance Humans European Union European union education Health policy MESH: Humans business.industry Policy Platform Public Health Environmental and Occupational Health International health lcsh:RA1-1270 06 Biological Sciences medicine.disease Folkhälsovetenskap global hälsa socialmedicin och epidemiologi 13. Climate action business |
| Zdroj: | PLoS Neglected Tropical Diseases PLoS Neglected Tropical Diseases, 2013, 7 (12), pp.e2320. ⟨10.1371/journal.pntd.0002320⟩ PLoS Neglected Tropical Diseases, 7(12):e2320. PUBLIC LIBRARY SCIENCE PLoS Neglected Tropical Diseases, Public Library of Science, 2013, 7 (12), pp.e2320. ⟨10.1371/journal.pntd.0002320⟩ PLoS Neglected Tropical Diseases, Vol 7, Iss 12, p e2320 (2013) |
| ISSN: | 1935-2735 1935-2727 |
| DOI: | 10.1371/journal.pntd.0002320⟩ |
| Popis: | Dengue is a major international public health concern and one of the most important arthropod-borne diseases [1]. Approximately 2.5 billion people—40% of the world's population, in over 100 countries—are at risk of dengue virus (DENV) infection [2]. In recent years the average annual incidence of dengue-related serious disease in many tropical counties has been rising dramatically, with the infection becoming endemic in areas where its occurrence was once sporadic [3]. The exponential increase over the last decade has been connected to societal changes, such as population growth and increasing urbanization [4]. In addition, it has been suggested that rising temperatures and global climate change may lead to the expansion of the range of major mosquito vectors into new areas, extension of the transmission season in current endemic areas, and increase in the mosquito species vectorial capacity [5]–[7]. Human migration (likely including infected hosts) and international travel are constantly introducing new vectors and pathogens into novel geographic areas [8]. For example, chikungunya virus was introduced into northeastern Italy in 2007, causing an outbreak with local transmission due to the presence of Aedes albopictus, a vector also capable of transmitting dengue virus [9]. In 2010, three authochthonous cases of dengue were reported in Europe, thereby highlighting the potential for global spread of this disease [10], [11]. The island of Madeira, where the mosquito vector Aedes aegypti is present, experienced a major dengue outbreak in the fall of 2012 [12], highlighting that the introduction of dengue to non-endemic areas is a real threat. Dengue has been neglected for many years. Major research gaps for dengue exist in the areas of epidemiology under changing climate conditions, clinical management, pathogenesis, vector control, surveillance and response, vaccines, drugs, and health policy research [13]. The European Commission (EC) launched a call under the Seventh Framework Programme with the title of “Comprehensive control of Dengue fever under changing climatic conditions” (http://ec.europa.eu/research/participants/portal/page/cooperation?callIdentifier=FP7-HEALTH-2011-single-stage). The focus of this call is summarized in Box 1. Within this framework, in 2011, the EC awarded a total of approximately €18 million to three consortia. The hosting institutions are Heidelberg University Hospital (Germany), the Institute Pasteur (Paris, France), and Umea University (Sweden). Each consortium has partners from countries with endemic and epidemic dengue. In total, the consortia comprise 38 partners from 21 countries, of which 11 are from Asia and Latin America, the current hotspots of dengue endemicity, and one from Africa (Figure 1). Figure 1 The world map of the three EU-funded dengue consortia. Box 1. European Commission Seventh Framework Programme FP7 Cooperation - Health HEALTH.2011.2.3.3-2: Comprehensive control of Dengue fever under changing climatic conditions. FP7-HEALTH-2011-single-stage Research should develop innovative tools for one or more of the following aspects: better diagnosis, surveillance, development of treatment, prevention and vaccination strategies, prevention, and/or prediction and prevention of the spread of dengue fever to previously uninfected regions (including Europe), in the context of climate change. Research may also include studies on the underlying pathogenesis with respect to viral and host factors that can predict disease severity and prepare for further development of new vaccines, antiviral compounds, and more targeted treatment schemes. Funding Scheme Specific International Cooperation Action (SICA) Collaborative Project (small- or medium-scale focused research project) target regions: Latin America and/or Asia. SICA aims to bring about the balanced participation of third countries in collaboration with European partners. Expected Impact Better tools, and the use thereof, for improved comprehensive control of dengue fever at a global level. Participation from both SICA target regions and Small and Medium Enterprises SMEs in the projects should help ensure innovation and exploitation of the results in this area/topic. The degree of such participation will be considered during the evaluation. Source: http://ec.europa.eu/research/health/infectious-diseases/emerging-epidemics/call-for-proposals_en.html The funding of such a large and complex research programme focusing on a single disease highlights the emphasis that the European Commission has put on dengue and its potential threat to Europe. In this paper, we present these three consortia and outline their scientific strategies and potential role within the international dengue research community. |
| Databáze: | OpenAIRE |
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