Expression of the Marburg I Single Nucleotide Polymorphism (MI-SNP) and the Marburg II Single Nucleotide Polymorphism (MII-SNP) of the Factor VII-Activating Protease (FSAP) Gene and Risk of Coronary Artery Disease (CAD): A Pilot Study in a Single Population
| Autor: | Bernhard Schieffer, Michael Worsch, Behnoush Parviz, Mariana S. Parahuleva, Hans Hölschermann, Michael Klassen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Population Pilot Projects Single-nucleotide polymorphism Coronary Artery Disease 030204 cardiovascular system & hematology Polymorphism Single Nucleotide Gastroenterology Coronary artery disease Angina 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors Clinical Research Internal medicine Diabetes mellitus Genetics medicine Humans SNP Genetic Predisposition to Disease 030212 general & internal medicine Myocardial infarction education Genetic Association Studies education.field_of_study Factor VII business.industry Serine Endopeptidases General Medicine medicine.disease chemistry Cardiovascular Diseases business |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| Popis: | BACKGROUND Factor VII-activating protease (FSAP) has a role in vascular inflammation and may have a role coronary artery disease (CAD). The aim of this study was to investigate the association between two naturally occurring single nucleotide polymorphisms (SNPs) in the FSAP gene and the risk of coronary artery disease (CAD). MATERIAL AND METHODS Of 733 patients, 173 patients had symptoms of angina, and 560 patients had CAD confirmed by coronary angiography. All patients were genotyped for SNPs of the FSAP gene, Marburg I (MI-SNP) and Marburg II (MII-SNP), using 5' exonuclease TaqMan assays. Logistic regression analysis was used to evaluate the association between two gene polymorphisms, metabolic and other cardiovascular risk factors in patients with CAD. RESULTS The presence of MI-SNP and MII-SNP FSAP gene polymorphisms were not associated with the presence of CAD. However, the MII-SNP polymorphism was significantly associated with a reduced risk of developing CAD (OR=0.422; 95% CI, 0.194-0.920; P=0.035); the MI-SNP polymorphism was associated with absence of hyperlipoproteinemia (OR=0.601; 95% CI, 0.344-1.051; P=0.074). There was no significant association between expression of the MI-SNP and MII-SNP FSAP gene polymorphisms and the incidence of myocardial infarction, or of a history of diabetes mellitus, arterial hypertension, obesity, or smoking. CONCLUSIONS The MI-SNP and MII-SNP FSAP gene polymorphisms were not predictive or prognostic biomarkers for CAD or its main risk factors. However, the presence of the MII-SNP polymorphism was associated with a reduced risk of developing CAD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|