Strategies for the synthesis of spiropiperidines – a review of the last 10 years

Autor:	Daniel Terence Tape, Paul A. Clarke, Samuel D. Griggs
Rok vydání:	2018
Předmět:	010405 organic chemistry Drug discovery Chemistry Organic Chemistry 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry Combinatorial chemistry Chemical space 0104 chemical sciences chemistry.chemical_compound Piperidine Physical and Theoretical Chemistry
Zdroj:	Organic & Biomolecular Chemistry. 16:6620-6633
ISSN:	1477-0539 1477-0520
Popis:	Spiropiperidines have gained in popularity in drug discovery programmes as medicinal chemists explore new areas of three-dimensional chemical space. This review focuses on the methodology used for the construction of 2-, 3- and 4- spiropiperidines, covering the literature from the last 10 years. It classifies the synthesis of each of the types of spiropiperidine by synthetic strategy: the formation of the spiro-ring on a preformed piperidine ring, and the formation of the piperidine ring on a preformed carbo- or heterocyclic ring. While 3- and 4-spiropiperidines are predominantly synthesised for drug discovery projects, 2-spiropiperidines are synthesised en route to natural products. The lack of 2- spiropiperidines in drug discovery is presumably due to limited general procedures for their synthesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc90e3dd7f06d5b923e51ca37f38650 https://doi.org/10.1039/c8ob01271g Zobrazit plný text záznamu