Prenatal Zidovudine Treatment Modifies Early Development of Rat Osteoid – Confocal Microspectroscopy Analysis
| Autor: | Zofia Drzazga, Wojciech Ciszek, Mariusz Binek |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty Time Factors Sociology and Political Science Confocal Clinical Biochemistry Fluorescence confocal laser scanning microscopy 010402 general chemistry 01 natural sciences Biochemistry Extracellular matrix 03 medical and health sciences Zidovudine medicine Fluorescence microscope Animals Tibia Collagen cross-links Spectroscopy 030304 developmental biology Bone growth 0303 health sciences Microscopy Confocal ECM Chemistry Osteoid Extracellular Matrix Rats 0104 chemical sciences Clinical Psychology Autofluorescence Microscopy Fluorescence Newborn rats Original Article Law Social Sciences (miscellaneous) medicine.drug |
| Zdroj: | Journal of Fluorescence |
| ISSN: | 1573-4994 1053-0509 |
| DOI: | 10.1007/s10895-019-02429-6 |
| Popis: | Autofluorescence of the bone extracellular matrix (ECM) has not been widely explored although the ECM plays a very important role in bone development. In our research we focused on examining the bone matrix of very young animals due to the intense growth process during the first month of life. Structure images and fluorescence spectra of the bone surface were carried out using confocal fluorescence microscope Eclipse Ti-S inverted CLSM (NIKON, Japan) for compact tibia of healthy 7-, 14- and 28-day-old rat newborns after prenatal zidovudine administration in comparison with control. Spectral features of ECM autofluorescence were analyzed statistically by taking into consideration p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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