Evolution of a Strategy for the Enantioselective Synthesis of (−)-Cajanusine
| Autor: | Brittany P. Witherspoon, M. Kevin Brown, Renyu Guo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cycloaddition Reaction
Bicyclic molecule Chemistry Enantioselective synthesis Stereoisomerism Oxidation reduction General Chemistry 010402 general chemistry Key features 01 natural sciences Biochemistry Combinatorial chemistry Article Catalysis Cycloaddition 0104 chemical sciences Cajanusine Bridged Bicyclo Compounds Colloid and Surface Chemistry Metals Heavy Stilbenes Oxidation-Reduction Isomerization |
| Zdroj: | J Am Chem Soc |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/jacs.0c00359 |
| Popis: | The first enantioselective synthesis of (−)-cajanusine is presented. Key features of the route include a rapid synthesis of the [4.2.0] bicyclooctane core by an enantioselective isomerization/stereoselective [2+2]-cycloaddition strategy as well as prominent use of catalytic methods for bond construction. The evolution of the approach is also presented that highlights unexpected roadblocks and how novel solutions were developed. |
| Databáze: | OpenAIRE |
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