Case study: Possible differences in phthalates exposure among the Czech, Hungarian, and Slovak populations identified based on the DEMOCOPHES pilot study results

Autor: Michal Jajcaj, Argelia Castaño, Karel Vrbík, Danuše Antošová, Jana Pavloušková, Elly Den Hond, Pierre Biot, Anke Joas, Marike Kolossa-Gehring, Andrea Krsková, Anna Pinkr Grafnetterová, Dominique Aerts, Miklós Náray, Greet Schoeters, Peter Rudnai, Katarina Halzlova, Kateřina Forysová, Szilvia Kozepesy, Reinhard Joas, Marta Esteban, Arno C. Gutleb, Jürgen Angerer, Marek Malý, Ludwine Casteleyn, Milena Černá, Holger M. Koch, Louis Bloemen
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Adult
Male
Slovakia
Spectrometry
Mass
Electrospray Ionization
Phthalic Acids
Target groups
Pilot Projects
Urine
010501 environmental sciences
01 natural sciences
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Urinary levels
Tandem Mass Spectrometry
Surveys and Questionnaires
Environmental health
Biomonitoring
Humans
Medicine
030212 general & internal medicine
Child
Biology
Chromatography
High Pressure Liquid
Czech Republic
0105 earth and related environmental sciences
General Environmental Science
Hungary
business.industry
Smoking
Monomethyl phthalate
Phthalate
Monoethyl phthalate
Environmental Exposure
Middle Aged
Chemistry
chemistry
Data Interpretation
Statistical
Environmental Pollutants
Female
Human medicine
Urine sample
business
Environmental Monitoring
Demography
Zdroj: Environmental research
Europe PubMed Central
ISSN: 0013-9351
Popis: Objective Phthalates and their metabolites are classified as endocrine modulators. They affect the hormonal balance in both children and adults. The aim of this publication was to compare the urinary levels of phthalate metabolites in selected populations of the Czech Republic (CZ), Slovakia (SK), and Hungary (HU) in relation to the sources of phthalate exposure identified by means of questionnaire (personal care products, floor and wall coverings, plastic toys, and some kinds of foods). Methods Data were obtained through the twin projects COPHES (COnsortium to Perform Human biomonitoring on a European Scale) and DEMOCOPHES (DEMOnstration of a study to COordinate and Perform Human biomonitoring on a European Scale) from 2009 to 2012. The target groups were children aged 611 years old and their mothers up to 45 years of age. The metabolites of phthalates (monomethyl phthalate (MMP), monoethyl phthalate (MEP), monobenzyl phthalate (MBzP), mono-cyclohexyl phthalate (MCHP), mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP), and mono-(2-ethyl-5-oxohexyl) phthalate (5OXO-MEHP)) were analysed in first morning urine samples. After enzymatic glucuronide cleavage, the urine sample analyses were performed using ultra-high-performance liquid chromatographyelectrospray ionization tandem mass spectrometry (UHPLCESI-MS/MS) in one laboratory that qualified in the External Quality Assessment exercises organised by COPHES. Results Significant differences in phthalate exposure between countries were revealed for children only but not for mothers. The concentrations of 5-OH-MEHP (P
Databáze: OpenAIRE
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