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Study Objectives: Obesity is a common problem, affecting over 40% of U.S. adults. It is a risk factor for chronic diseases such as type 2 diabetes, heart disease, and some cancers. There is some evidence it may also be associated with increased morbidity for COVID-19–associated illness. The authors sought to quantify the relationship between BMI and mortality after COVID-19. Methods: This was an observational retrospective cohort study from 178 hospitals from a large health system across the United States. Patients who presented to the hospital with confirmed COVID-19 between January 1st, 2020, and September 1st, 2020 were evaluated for outcomes during hospitalization, including disease severity by level of care, intensive care unit admission, hospital length of stay, and in-hospital death. Disease severity was classified as moderate, severe or critical. Moderate disease was defined as highest level of care being the medical floor;critical disease was defined as highest level of care being the intensive care unit (ICU) and requiring mechanical ventilation and/or vasopressor support;and severe disease was defined as highest level of care being ICU but not meeting criteria for critical disease. Results: There were 45,340 patients in the cohort. The median age was 63 years (IQR 49-75). Forty eight percent of the cohort was female. Median overall BMI was 29.3 (IQR 25.1 to 34.7). In men median BMI was 28.6 (IQR 25.0 to33.3). In women the median BMI was 30.1 (IQR 25.4 to 36.2). Men had a significantly lower BMI when compared to women (P |
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