Mango leaf tea promotes hepatoprotective effects in obese rats
| Autor: | Marcia Paranho Veloso, Sônia Machado Rocha Ribeiro, Camila de Morais Coelho, Renata Celi Lopes Toledo, Hércia Stampini Duarte Martino, Maria Eliza de Castro Moreira, José Humberto de Queiroz, Cláudio Mafra, Laércio dos Anjos Benjamin, Natalia Medina Ramírez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Hepatic steatosis Antioxidant medicine.medical_treatment Medicine (miscellaneous) medicine.disease_cause NF-κB 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine TX341-641 Food science Mangiferin chemistry.chemical_classification Nutrition and Dietetics Nutrition. Foods and food supply food and beverages Mangifera indica Lipid metabolism medicine.disease Obesity Stress oxidative Bioactive compound 030104 developmental biology Enzyme chemistry 030220 oncology & carcinogenesis Molecular docking Steatosis Liver histology Oxidative stress Food Science |
| Zdroj: | Journal of Functional Foods, Vol 49, Iss, Pp 437-446 (2018) |
| ISSN: | 1756-4646 |
| Popis: | As mango leaf tea contains mangiferin and other bioactive compounds, this study investigated its anti-inflammatory, antioxidant and hepatoprotective effects on rats with high-fat induced obesity. Three groups were established: a control group (AIN93M diet), an obese group (high-fat diet HFD) and a treatment group (HFD with mango leaf tea for 8 weeks). Mango leaf tea increased antioxidant enzymes, total antioxidant capacity, AdipoR2 and PPAR-α mRNA and proteins expressions and, it also inhibited the NF-κB p65 and SREBP1c genes expressions in the liver. This beverage also leads to Cpt1 overexpression and a significant decrease in the accumulation of fat droplets, improving the hepatic steatosis. Molecular docking suggested a positive interaction between mangiferin, the main bioactive compound of mango leaf tea, and PPAR-α. Mango leaf tea exhibited a hepatoprotective effect through activating PPARα and decreasing the NF-κB p65 expressions, reducing oxidative stress and steatosis, and improving the lipid metabolism. |
| Databáze: | OpenAIRE |
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