Effects of Freeze-Dried Grape Powder on High-Density Lipoprotein Function in Adults with Metabolic Syndrome: A Randomized Controlled Pilot Study

Autor: Quinn Duclos, Bruno S Lemos, Diana M DiMarco, Maria Luz Fernandez, Courtney L. Millar, Christopher N. Blesso, Chelsea Garcia, Gregory H Norris
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Time Factors
Endocrinology
Diabetes and Metabolism
Anti-Inflammatory Agents
030204 cardiovascular system & hematology
Antioxidants
chemistry.chemical_compound
0302 clinical medicine
High-density lipoprotein
Vitis
Hypolipidemic Agents
Metabolic Syndrome
Cross-Over Studies
Middle Aged
PON1
Treatment Outcome
lipids (amino acids
peptides
and proteins)
Female
medicine.symptom
Inflammation Mediators
Powders
Lipoproteins
HDL
Adult
medicine.medical_specialty
Inflammation
03 medical and health sciences
Double-Blind Method
Internal medicine
Internal Medicine
medicine
Humans
Triglycerides
Aged
business.industry
Aryldialkylphosphatase
Plant Extracts
nutritional and metabolic diseases
medicine.disease
Connecticut
030104 developmental biology
Endocrinology
Freeze Drying
chemistry
Polyphenol
Fruit
Metabolic syndrome
Insulin Resistance
business
Function (biology)
Biomarkers
Lipoprotein
Zdroj: Metabolic syndrome and related disorders. 16(9)
ISSN: 1557-8518
Popis: High-density lipoprotein (HDL) particles are protective against atherosclerosis. However, HDL function is impaired in metabolic syndrome (MetS) due to low-grade inflammation and dyslipidemia. Foods containing polyphenols, such as grapes, may prevent HDL dysfunction via antioxidant or anti-inflammatory effects. We evaluated the effects of grape powder ingestion on measures of HDL function in adults with MetS.Twenty adults (age: 32-70 years; body mass index: 25.3-45.4 kg/mAfter 4 weeks, GRAPE did not alter the serum PON1 activity or other markers of HDL function compared with placebo. Measures of HDL function were positively correlated with each other and inversely with measures of insulin resistance and inflammation. GRAPE intake led to a significant reduction in fasting plasma triglycerides compared with placebo (P = 0.032). No other significant effects of GRAPE were observed for other plasma lipids, anthropometrics, or metabolic measures.Grape powder consumption did not impact HDL function in this cohort of adults with MetS. However, it was shown to improve fasting triglycerides, a risk factor for cardiovascular disease.
Databáze: OpenAIRE
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