QT interval abnormalities and heart rate variability in patients with cirrhosis
| Autor: | Kharrat Jamel, Ltaief Kamel, Gargouri Dalila, Elloumi Hela, Kraiem Sondos, Kamoun Sofien, Ouakaa Asma |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Cirrhosis Propranolol QT interval 03 medical and health sciences 0302 clinical medicine Heart Rate Internal medicine Heart rate medicine Heart rate variability Humans Prospective Studies Prospective cohort study business.industry Gastroenterology Dysautonomia medicine.disease Long QT Syndrome 030220 oncology & carcinogenesis Cardiology Etiology 030211 gastroenterology & hepatology medicine.symptom business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology. 21(4) |
| ISSN: | 2090-2387 |
| Popis: | We aimed to assess the relationship of the QT interval and heart rate variability with the severity and aetiology of cirrhosis and determine the effect of propranolol on them.This prospective study included 44 patients with cirrhosis categorised into three groups based on the Child-Pugh score: groups 1, 2 and 3 (with 12, 15 and 15 patients, respectively). Demographic characteristics, propranolol administration, severity of cirrhosis evaluated by the Child-Pugh score, aetiology of cirrhosis, and serum sodium, potassium and calcium levels were evaluated. All patients underwent 24 h-Holter monitoring. Corrected QT interval (QTc), average heart rate, standard deviation of normal-to-normal intervals (SDNN) and corrected SDNN (cSDNN) were evaluated.The average QTc was significantly longer in group 3 than in groups 1 and 2 (453.4 ± 17.4 vs 422.8 ± 18.6 and 428.9 ± 17.24 ms, p 0.001). The median SDNN was 70 ms and was significantly lower in group 3 vs groups 1 and 2 (77; interquartile range [IQR], 67-89.5 vs 57; IQR, 38-68 and 75 ms; IQR, 61-81 ms, p = 0.003). cSDNN was significantly lower in group 3 vs groups 1 and 2 (200.0 ± 42.6 vs 254.5 ± 75.3 and 277.8 ± 110.6 ms, p = 0.022). Propranolol administration resulted in a significant increase in the average SDNN value but had no effect on cSDNN or QTc. QTc was associated with the Child-Pugh class (p 0.001), viral aetiology (p = 0.009) and sex (p = 0.010); SDNN was associated with the mean heart rate (p = 0.015) and Child-Pugh class (p = 0.024).QTc interval prolongation and decreased SDNN are common in cirrhosis. Their prevalence is closely associated with disease severity. Propranolol has no effects on cSDNN or QTc. |
| Databáze: | OpenAIRE |
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