Reteplase in the treatment of thrombosed hemodialysis grafts
| Autor: | Harold Mitty, Jaime Uribarri, Victoria Teodorescu, Joseph Vassalotti, A Falk, F. Scott Nowakowski, Jeffrey Guller |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Percutaneous medicine.medical_treatment Venography Reteplase Statistics Nonparametric Fibrinolytic Agents Blood vessel prosthesis Renal Dialysis Angioplasty medicine Humans Radiology Nuclear Medicine and imaging Thrombolytic Therapy Prospective Studies Polytetrafluoroethylene Vascular Patency Aged Aged 80 and over medicine.diagnostic_test business.industry Heparin Graft Occlusion Vascular Thrombosis Thrombolysis Middle Aged medicine.disease Recombinant Proteins Surgery Blood Vessel Prosthesis Treatment Outcome Tissue Plasminogen Activator Female Hemodialysis Cardiology and Cardiovascular Medicine business Angioplasty Balloon medicine.drug |
| Zdroj: | Journal of vascular and interventional radiology : JVIR. 12(11) |
| ISSN: | 1051-0443 |
| Popis: | To prospectively evaluate the efficacy and safety of reteplase with percutaneous transluminal angioplasty (PTA) in the treatment of thrombosed polytetrafluoroethylene hemodialysis arteriovenous grafts (AVGs).Forty-two patients were entered into the study. Sixty-two procedures in 43 grafts were performed. One unit of reteplase and 4,000 units of heparin were administered into the AVGs. Routine venography and percutaneous transluminal angioplasty (PTA) was then performed. Patients were transferred for hemodialysis immediately after the procedure.Technical success was achieved in 92% of the cases. Four cases involved intentional repeat thrombosis because of poor outflow and/or need for a new graft site. Minor complications occurred in 6.5% of the cases. No major complications occurred. The mean procedure time for experienced versus less-experienced interventionalists was significantly shorter (P.001). Primary patency rates were 50%, 34%, and 34% at 30, 90, and 180 days, respectively.Reteplase in conjunction with heparin and PTA is a safe and effective means of thrombolysis of AVGs. Its efficacy is comparable to that of other available thrombolytic drugs. |
| Databáze: | OpenAIRE |
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