Calprotectin (S100A8/A9) and S100A12 are associated with measures of disease activity in a longitudinal study of patients with rheumatoid arthritis treated with infliximab

Autor: Johan G. Brun, Hilde Haugedal Nordal, Roland Jonsson, Eidsheim M, Anne-Kristine Halse, Hordvik M
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Wrist Joint
Arthritis
Gastroenterology
Severity of Illness Index
Arthritis
Rheumatoid
0302 clinical medicine
Immunology and Allergy
Longitudinal Studies
Prospective Studies
skin and connective tissue diseases
Prospective cohort study
medicine.diagnostic_test
biology
General Medicine
Middle Aged
C-Reactive Protein
Erythrocyte sedimentation rate
Rheumatoid arthritis
Antirheumatic Agents
Drug Therapy
Combination
Female
medicine.drug
musculoskeletal diseases
Adult
medicine.medical_specialty
Hand Joints
Prednisolone
Immunology
Enzyme-Linked Immunosorbent Assay
Blood Sedimentation
Peptides
Cyclic
03 medical and health sciences
Young Adult
Rheumatology
Rheumatoid Factor
Internal medicine
Foot Joints
medicine
Rheumatoid factor
Calgranulin B
Humans
Calgranulin A
Glucocorticoids
Aged
030203 arthritis & rheumatology
business.industry
C-reactive protein
S100A12 Protein
medicine.disease
Infliximab
Radiography
030104 developmental biology
Methotrexate
biology.protein
Calprotectin
business
Leukocyte L1 Antigen Complex
Biomarkers
Zdroj: Scandinavian journal of rheumatology. 45(4)
ISSN: 1502-7732
Popis: The pro-inflammatory proteins calprotectin (a heterocomplex of S100A8/A9) and S100A12 have been associated with disease activity in rheumatoid arthritis (RA). The aim of this study was to compare their potential as biomarkers in a prospective study of RA patients starting with infliximab as their first biological disease-modifying anti-rheumatic drug (DMARD).Thirty-nine RA patients were examined and serum samples collected when starting with infliximab and after 3, 6, and 12 months. Calprotectin and S100A12 were analysed by enzyme-linked immunosorbent assays (ELISAs) and, together with C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), measured at all time points. A disease activity score of 28 joints (DAS28) was calculated. Radiographs of the hands, wrists, and feet were taken at baseline and after 3 years, and assessed according to the modified Sharp/van der Heijde (SvH) score. Responsiveness was evaluated according to the European League of Associations for Rheumatology (EULAR) response criteria based on 28 joints.Both S100 proteins were significantly higher in seropositive than in seronegative patients (p = 0.01). Calprotectin correlated significantly with CRP (ρ = 0.51-0.75), ESR (ρ = 0.32-0.52), and DAS28 (ρ = 0.32-0.62). S100A12 correlated with calprotectin (ρ = 0.62-0.77) and CRP (ρ = 0.32-0.63). The S100 proteins, and especially calprotectin (ρ = 0.23-0.39), showed weak associations with radiographic progression, unlike CRP/ESR. None of the S100 proteins could predict responsiveness.Calprotectin showed the strongest correlation with measures of disease activity and may be better than S100A12 when evaluating disease activity in RA patients. More extensive studies are needed to further compare the predictive value of the S100 proteins relative to radiographic progression.
Databáze: OpenAIRE
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