Molecular link between circadian clocks and cardiac function: a network of core clock, slave clock, and effectors
| Autor: | Lilei Zhang, Weiyi Xu, Mukesh K. Jain |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pharmacology Cell specific Cardiac function curve Effector Circadian clock Enslaved Persons Biology 030226 pharmacology & pharmacy Article Circadian Rhythm 03 medical and health sciences Mice 030104 developmental biology 0302 clinical medicine Mammalian cell Circadian Clocks Drug Discovery Animals Humans Circadian rhythm Molecular clock Slave clock Neuroscience |
| Zdroj: | Curr Opin Pharmacol |
| ISSN: | 1471-4973 |
| Popis: | The circadian rhythm has a strong influence on both cardiac physiology and disease in humans. Preclinical studies primarily using tissue-specific transgenic mouse models have contributed to our understanding of the molecular mechanism of the circadian clock in the cardiovascular system. The core clock driven by CLOCK:BMAL1 complex functions as a universal timing machinery that primarily sets the pace in all mammalian cell types. In one specific cell or tissue type, core clock may control a secondary transcriptional oscillator, conceptualized as slave clock, which confers the oscillatory expression of tissue-specific effectors. Here, we discuss a core clock-slave clock-effectors network, which links the molecular clock to cardiac function. |
| Databáze: | OpenAIRE |
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