Evaluation of Antinociceptive Activity of Ethanol Extract of Leaves of Adenanthera pavonina

Autor: Ambia Khatun, Mohammad Zafar Imam, Md. Moniruzzaman
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Evidence-Based Complementary and Alternative Medicine, Vol 2015 (2015)
Evidence-based Complementary and Alternative Medicine : eCAM
ISSN: 1741-427X
DOI: 10.1155/2015/412497
Popis: Adenanthera pavoninais a deciduous tree commonly used in the traditional medicine to treat inflammation and rheumatism. The aim of this study was to evaluate the antinociceptive activity of ethanol extract of leaves ofA. pavonina(EEAP). EEAP was investigated using various nociceptive models induced thermally or chemically in mice including hot plate and tail immersion test, acetic acid-induced writhing, and glutamate- and formalin-induced licking tests at the doses of 50, 100, and 200 mg/kg body weight (p.o.). In addition, to assess the possible mechanisms, involvement of opioid system was verified using naloxone (2 mg/kg) and cyclic guanosine monophosphate (cGMP) signaling pathway by methylene blue (MB; 20 mg/kg). The results have demonstrated that EEAP produced a significant and dose-dependent increment in the hot plate latency and tail withdrawal time. It also reduced the number of abdominal constrictions and paw lickings induced by acetic acid and glutamate respectively. EEAP inhibited the nociceptive responses in both phases of formalin test. Besides, the reversal effects of naloxone indicated the association of opioid receptors on the exertion of EEAP action centrally. Moreover, the enhancement of writhing inhibitory activity by MB suggests the possible involvement of cGMP pathway in EEAP-mediated antinociception. These results prove the antinociceptive activity of the leaves ofA. pavoninaand support the traditional use of this plant.
Databáze: OpenAIRE
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