Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons
| Autor: | F. G. De Waart, Evert G. Schouten, B M von Blomberg, E.G.M. Pallast, F.J. Kok, G Doekes, H.C.M. Fonk |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Cellular immunity medicine.medical_treatment Medicine (miscellaneous) Body Mass Index T helper cells chemistry.chemical_compound Elderly Immune system Double-Blind Method Internal medicine medicine Humans Vitamin E Hypersensitivity Delayed VLAG Human Nutrition & Health Aged Netherlands Aged 80 and over Immunity Cellular Delayed-type hypersensitivity Nutrition and Dietetics Dose-Response Relationship Drug business.industry Interleukins Humane Voeding & Gezondheid Vakgroep Gezondheidsleer Interleukin Cellular immune response T helper cell Environmental and Occupational Health Group Endocrinology Cytokine medicine.anatomical_structure chemistry Delayed hypersensitivity Immunology Cytokines Female business |
| Zdroj: | American Journal of Clinical Nutrition, 69, 1273-1281 American Journal of Clinical Nutrition 69 (1999) |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/69.6.1273 |
| Popis: | Background: It has been suggested that vitamin E can counteract the age-associated decline in cellular immune responsiveness (CIR). Particularly, T helper cell type 1 (Thl) activity, ie, interferon (IFN) γ-producing Thl activity and, hence, delayed-type hypersensitivity (DTH) would be enhanced by vitamin E supplementation. Objective: Our aim was to study the effects of 6 mo supplementation with 50 and 100 mg vitamin E on CIR in the elderly. Design: A double-blind, placebo-controlled trial was conducted in 161 healthy elderly subjects aged 65-80 y. CIR was measured in vivo by means of DTH skin tests and in vitro by assessing the production of interleukin (IL) 2, IFN-γ (a typical Thl cytokine), and IL-4 (a typical Th2 cytokine) by peripheral blood mononuclear cells after stimulation with phytohemagglutinin. Results: Both DTH and IL-2 production showed a trend toward increased responsiveness with increasing dose of vitamin E. However, IFN-γ production decreased whereas IL-4 production increased in the groups receiving vitamin E. Only the change in the number of positive DTH reactions was borderline significantly larger in the 100-mg vitamin E group than in the placebo group (P = 0.06, Bonferroni adjusted). Subjects receiving 100 mg vitamin E with low baseline DTH reactivity or who were physically less active had a significantly larger increase in the cumulative diameter of the skin induration resulting from the DTH test than did the placebo group (P = 0.03), although this difference was not significant after Bonferroni correction (P = 0.07). Conclusion: Possible beneficial effects of 100-mg vitamin E supplementation may be more pronounced in particular subgroups of elderly subjects. |
| Databáze: | OpenAIRE |
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