Comparison of nebulized epinephrine and terbutaline in patients with acute severe asthma: a controlled trial
| Autor: | Cendrine Godet, Jean-Pierre Frat, René Robert, Michèle Adoun, Pierre Doré, Jean Rouffineau |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Adolescent Epinephrine Terbutaline Peak Expiratory Flow Rate Pilot Projects Critical Care and Intensive Care Medicine law.invention Double-Blind Method Randomized controlled trial law medicine Humans Asthma Aerosols Cross-Over Studies business.industry Nebulizers and Vaporizers Respiration Adrenergic beta-Agonists Middle Aged medicine.disease Crossover study Bronchodilator Agents Oxygen Treatment Outcome Tolerability Methylprednisolone Acute severe asthma Anesthesia Acute Disease Female business medicine.drug |
| Zdroj: | Journal of Critical Care. 19:99-102 |
| ISSN: | 0883-9441 |
| DOI: | 10.1016/j.jcrc.2004.04.005 |
| Popis: | To compare the efficacy and tolerability of nebulized adrenaline and terbutaline in acute severe asthma.Prospective pilot randomized double-blind cross-over trial.Emergency department of a university hospital.Thirty-eight patients admitted with severe acute asthma. Each patient received adrenaline (3 mg) and terbutaline (5 mg) nebulizations over 20 min in randomized order. Additional treatment comprised methylprednisolone, intravenous hydration, and oxygen. The efficacy and tolerability of the two drugs were evaluated at the end of each nebulization as well as potential synergistic effects.Eighteen patients received adrenaline first, and 20 received terbutaline first. Peak expiratory flow (PEF) improved significantly in both groups after the first nebulization (from 157 L/min +/- 111 L/min to 199 L/min +/- 134 L/min with adrenaline, P.01; and from 142 L/min +/- 65 L/min to 193 L/min +/- 181 L/min with terbutaline, P.01). Both drugs induced a significant decrease in respiratory frequency. The improvement in PaO2 was only significant with terbutaline. Respiratory frequency, PEF and PaO2 were not improved by the second nebulization. No adverse effects were observed.Adrenaline nebulization was as effective and as well tolerated as terbutaline in acute severe asthma. No synergistic effect between terbutaline and adrenaline was observed. |
| Databáze: | OpenAIRE |
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