Fasting and postprandial lipid parameters: A comparative evaluation of cardiovascular risk assessment in prediabetes and diabetes
| Autor: | Karthikeyan Pethusamy, Montosh Chakraborty, Prerna Singh, Jyothi M P Dsouza, Pandurang Vithal Thatkar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Blood lipids lcsh:Medicine 030209 endocrinology & metabolism Context (language use) prediabetes postprandial lipid profile 03 medical and health sciences 0302 clinical medicine Insulin resistance Diabetes mellitus Internal medicine Medicine 030212 general & internal medicine Prediabetes fasting lipid profile medicine.diagnostic_test diabetes business.industry dyslipidemia lcsh:R medicine.disease Postprandial Endocrinology Original Article business Lipid profile Dyslipidemia |
| Zdroj: | Journal of Family Medicine and Primary Care, Vol 9, Iss 1, Pp 287-292 (2020) BASE-Bielefeld Academic Search Engine Journal of Family Medicine and Primary Care |
| ISSN: | 2249-4863 |
| Popis: | Context: Dyslipidemia plays a crucial role in atherogenesis, in both prediabetes and diabetes. There persists a lacuna in the evaluation of postprandial lipid parameters in prediabetes. Aims: To comparatively evaluate fasting and postprandial blood lipid parameters and atherogenic lipid ratios for cardiovascular risk assessment, in prediabetes and diabetes. Materials and Methods: Fifty-one patients diagnosed with diabetes mellitus and thirty-two with prediabetes were selected for the study. Lipid profile and blood glucose were analyzed in fasting and postprandial blood samples. Statistical Analysis Used: Kolmogorov–Smirnov test, Shapiro–Wilk test, one-way ANOVA, and Pearson's regression analysis were applied. Results: Postprandially, triglycerides (TG) was increased significantly in diabetes compared to controls (P < 0.01) and prediabetics (P < 0.05). Among the lipid ratios, triglyceride/high density lipoprotein (TG/HDLc) was significantly increased postprandially in diabetes compared to controls (P < 0.05). A comparative analysis of fasting and postprandial parameters within each group showed a significant increase in postprandial TG/HDLc compared to the fasting state in prediabetes (P < 0.001) and diabetes (P < 0.001). Postprandial TG (P < 0.01) and TG/HDLc (P < 0.01) showed a stronger correlation with HbA1c compared to fasting TG (P < 0.05) and TG/HDLc (P > 0.05). The prevalence of dyslipidemia and insulin resistance was higher in postprandial state than the fasting state in prediabetes and diabetes. Conclusions: Postprandial TG and the TG/HDLc reflect lipid abnormalities than the corresponding fasting variables in diabetes and prediabetes. Postprandial TG and TG/HDLc are better reflectors of cardiovascular status in prediabetes and diabetes. |
| Databáze: | OpenAIRE |
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