Conjunctival melanoma: association of cyclooxygenase-2 tumor expression to prognosis

Autor: Maria Filomena Gaspar, Rui Proença, Júlia Fernandes, Mariana Santos, Cristina Fonseca, Rita Pinto-Proença
Předmět:
Oncology
Male
Disease
Conjunctival Neoplasms/enzymology
Metastasis
0302 clinical medicine
Melanoma/pathology
Medicine
Cyclooxygenase-2
Lymph node
Cyclooxygenase 2/metabolism
Melanoma
Aged
80 and over
Prognostic factor
Middle Aged
Prognosis
Immunohistochemistry
Sensory Systems
medicine.anatomical_structure
CHLC OFT
030220 oncology & carcinogenesis
Lymphatic Metastasis
Female
Adult
medicine.medical_specialty
Conjunctival Neoplasms/pathology
Conjunctival Neoplasms
03 medical and health sciences
Cellular and Molecular Neuroscience
Young Adult
Conjunctival melanoma
Internal medicine
Adjuvant therapy
Biomarkers
Tumor
Humans
Pathological
Aged
Retrospective Studies
business.industry
Retrospective cohort study
COX-2
medicine.disease
Ophthalmology
Cyclooxygenase 2
Biomarkers
Tumor/metabolism
Melanoma/enzymology
030221 ophthalmology & optometry
business
Conjunctival Melanoma
Zdroj: CIÊNCIAVITAE
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
Popis: PURPOSE: Conjunctival melanoma is a rare but potentially lethal tumor. Its biologic profile is still largely unknown, with recent studies aiming at establishing histopathological and genetic tumor profiles. The aim of this study was to analyze the association between clinicopathological characteristics and tumor expression of cyclooxygenase-2 (COX-2) to prognosis, assessing its usefulness as a possible prognostic marker. METHODS: Case series of 50 patients from 1991 to 2008 with pathologically proven conjunctival melanoma. Demographic, clinical, and pathological characteristics were evaluated by reviewing clinical files and pathology. Expression of COX-2 was studied by immunohistochemistry of formalin-fixed paraffin-embedded tissue samples of 20 melanomas. Samples were classified in a score which included intensity of staining and percentage of cells with positive reactivity. RESULTS: Clinicopathological features significantly associated (p
Databáze: OpenAIRE
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