Candidemia Diagnosis With T2 Nuclear Magnetic Resonance in a PICU: A New Approach
| Autor: | E. Álvarez-Rojas, Javier Pemán, Iker Falces-Romero, Julio García-Rodríguez, Paloma Dorao Martínez-Romillo, Miguel Rodríguez Rubio, J.J. Menéndez-Suso, Cristina Schuffelmann-Gutiérrez, Belén Calderón-Llopis, Abelardo García de Lorenzo, Elena Pérez-Acosta, D. Rodriguez-Álvarez, C. Verdú-Sánchez, Emilio Cendejas-Bueno, Jesús Mingorance, María Pilar Romero-Gómez, Pedro de la Oliva, Ana Gómez-Zamora, Federico Goded-Rambaud, Irene Amores-Hernández, María Laplaza-González, Iría Durán-Lorenzo, Emilio Maseda, Miguel Río-García, Luis Escosa-García |
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| Rok vydání: | 2020 |
| Předmět: |
Antifungal
Magnetic Resonance Spectroscopy Adolescent medicine.drug_class medicine.medical_treatment Hematopoietic stem cell transplantation 030204 cardiovascular system & hematology Intensive Care Units Pediatric Critical Care and Intensive Care Medicine T2Candida Candida infections 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance medicine Humans Blood culture Prospective Studies Child Prospective cohort study Candida medicine.diagnostic_test business.industry candidemia Infant Newborn Candidemia Infant 030208 emergency & critical care medicine Child Preschool Pediatrics Perinatology and Child Health Observational study Solid organ transplantation business pediatric intensive care unit Pediatric population |
| Zdroj: | PEDIATRIC CRITICAL CARE MEDICINE r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| ISSN: | 1529-7535 |
| Popis: | Objectives Early diagnosis of invasive Candida infections is a challenge for pediatricians, intensivists, and microbiologists. To fill this gap, a new nanodiagnostic method has been developed using manual application of T2 nuclear magnetic resonance to detect Candida species. The aim of this study was to evaluate, prospectively, the usefulness as a tool diagnosis of the T2Candida panel in pediatric patients admitted at the PICU compared with blood culture. Design This is a prospective, observational, and unicentric study to compare T2Candida results with simultaneous blood cultures for candidemia diagnose. Setting This study was carried out in a 1,300-bed tertiary care hospital with a 16-bed medical-surgical PICU. Patients Sixty-three patients from 0 to 17 years old were enrolled in this study, including those undergoing solid organ transplantation (kidney, liver, pulmonary, multivisceral, intestinal, and heart) and hematopoietic stem cell transplantation. Measurements and main results Seven patients were positive by the T2Candida test. Only two of them had the simultaneous positive blood culture. T2Candida yielded more positive results than blood cultures. Conclusions T2Candida might be useful for the diagnosis of candidemia in PICUs. The prevalence of candidemia might be underestimated in this pediatric population. The use of this diagnostic tool in these units may help clinicians to start adequate and timely antifungal treatments. |
| Databáze: | OpenAIRE |
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